Quantitative Hybrid Cardiac [
PET
heart failure
large animal model
magnetic resonance imaging
myocardial regeneration
nuclear cardiology
proteomics
stem cells
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
11 Sep 2020
11 Sep 2020
Historique:
received:
29
05
2020
accepted:
05
06
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
Cardiosphere-derived cells (CDCs) are progenitor cells derived from heart tissue and have shown promising results in preclinical models. APOSEC, the secretome of irradiated peripheral blood mononuclear cells, has decreased infarct size in acute and chronic experimental myocardial infarction (MI). We enhanced the effect of CDCs with APOSEC preconditioning (apoCDC) and investigated the reparative effect in a translational pig model of reperfused MI. Supernatants of CDCs, assessed by proteomic analysis, revealed reduced production of extracellular matrix proteins after
Identifiants
pubmed: 32671138
doi: 10.1016/j.omtm.2020.06.008
pii: S2329-0501(20)30132-7
pmc: PMC7341058
doi:
Types de publication
Journal Article
Langues
eng
Pagination
354-366Informations de copyright
© 2020 The Author(s).
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