Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
05 2020
Historique:
received: 24 09 2019
accepted: 10 03 2020
entrez: 17 7 2020
pubmed: 17 7 2020
medline: 17 7 2020
Statut: epublish

Résumé

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move between genetic lineages is an open question, which we address in the context of antibiotic resistance in

Identifiants

pubmed: 32671212
doi: 10.1126/sciadv.aaz6137
pii: aaz6137
pmc: PMC7314567
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaaz6137

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI106786
Pays : United States
Organisme : NIGMS NIH HHS
ID : U01 GM110721
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM088558
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Auteurs

Sonja Lehtinen (S)

Big Data Institute, University of Oxford, Oxford, UK.
Institute of Integrative Biology, Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland.

Claire Chewapreecha (C)

Wellcome Sanger Institute, Hinxton, UK.
Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.
Bioinformatics and Systems Biology Program, School of Bioresource and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.

John Lees (J)

Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.

William P Hanage (WP)

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Marc Lipsitch (M)

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Nicholas J Croucher (NJ)

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Stephen D Bentley (SD)

Wellcome Sanger Institute, Hinxton, UK.

Paul Turner (P)

Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.
Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

Christophe Fraser (C)

Big Data Institute, University of Oxford, Oxford, UK.

Rafał J Mostowy (RJ)

Big Data Institute, University of Oxford, Oxford, UK.
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.

Classifications MeSH