Impaired NK cell activation during acute dengue virus infection: A contributing factor to disease severity.
Hematological system
Immunology
Immunopathogenesis
Infectious disease
Microbiology
NK cell response
Public health
Severe dengue viral infection
Virology
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
16
04
2019
revised:
23
05
2020
accepted:
23
06
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
Dengue viral (DENV) infection has a broad clinical spectrum ranging from classical febrile illness to life-threatening disease. Literature suggests that spectrum of illness could be due to differences in innate immune-responses; however, the knowledge is still at infancy. Amongst the various cells involved in innate immune responses, NK cells play a central role, particularly in anti-viral immunity. Thus in this study we have evaluated the role of NK-cells during acute-DENV infection and its influence on severity of disease, by analyzing activation, cytotoxic receptors, cytolytic granule contents and degranulation markers on NK-cells during different stages of infection. Based on the clinical manifestations and severity of the disease, DENV patients were classified into patients with dengue without warning signs (DF), dengue with warning signs (DFWS) and severe dengue (SD) patients. During acute-DENV infection, though there was no alteration in frequency of NK-cells, significant increase in frequency of CD56
Identifiants
pubmed: 32671251
doi: 10.1016/j.heliyon.2020.e04320
pii: S2405-8440(20)31164-6
pii: e04320
pmc: PMC7339061
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e04320Informations de copyright
© 2020 Published by Elsevier Ltd.
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