Intracranial anaplastic solitary fibrous tumor/hemangiopericytoma: immunohistochemical markers for definitive diagnosis.
Adult
Aged
Biomarkers, Tumor
/ metabolism
Diagnosis, Differential
Female
Follow-Up Studies
Hemangiopericytoma
/ diagnostic imaging
Humans
Male
Meningeal Neoplasms
/ diagnostic imaging
Meningioma
/ diagnostic imaging
Middle Aged
Neoplasm Recurrence, Local
/ diagnostic imaging
STAT6 Transcription Factor
/ metabolism
Solitary Fibrous Tumors
/ diagnostic imaging
Anaplastic
Hemangiopericytoma
Meningioma
STAT6
Solitary fibrous tumor
Journal
Neurosurgical review
ISSN: 1437-2320
Titre abrégé: Neurosurg Rev
Pays: Germany
ID NLM: 7908181
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
28
04
2020
accepted:
06
07
2020
revised:
15
06
2020
pubmed:
17
7
2020
medline:
30
6
2021
entrez:
17
7
2020
Statut:
ppublish
Résumé
Intracranial anaplastic hemangiopericytoma (AHPC) is a rare and malignant subset of solitary fibrous tumor/hemangiopericytoma (SFT/HPC) as per the WHO 2016 Classification of Tumors of the Central Nervous System. AHPC portends a poor prognosis and is associated with higher rates of recurrence/metastasis in comparison with SFT/HPC. Accordingly, it is critical to continue to define the clinical course of patients with AHPC and in so doing further refine clinicopathologic/immunohistochemical (IHC) criteria needed for definitive diagnosis. Herein, we describe clinical/histological characteristics of six patients with AHPC. In addition, we reviewed and analyzed the expression of various IHC markers reported within the literature (i.e., a total of 354 intracranial SFT/HPCs and 460 meningiomas). Histologically, tumors from our six patients were characterized by a staghorn-like vascular pattern, mitotic cells, and strong nuclear atypia. Immunohistochemically, all tumors displayed positive nuclear staining for STAT6; other markers, including CD34 and Bcl-2, were expressed only in three patients. Analysis of IHC expression patterns for SFT/HPC and meningioma within the literature revealed that nuclear expression of STAT6 had the highest specificity (100%) for SFT/HPC, followed by ALDH1 (97.2%) and CD34 (93.6%). Of note, SSTR2A (95.2%) and EMA (85%) displayed a high specificity for meningioma. Anaplastic SFT/HPC is a tumor with poor prognosis that is associated with higher rates of recurrence and metastasis in comparison with SFT/HPC. Given that anaplastic SFT/HPC requires more aggressive treatment than meningioma despite of a similar presentation on imaging, it is crucial to be able to distinguish between these tumors.
Identifiants
pubmed: 32671693
doi: 10.1007/s10143-020-01348-6
pii: 10.1007/s10143-020-01348-6
doi:
Substances chimiques
Biomarkers, Tumor
0
STAT6 Transcription Factor
0
STAT6 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1591-1600Références
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