The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication.
brown adipose tissue
interorgan communication
lipid homeostasis
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
03 09 2020
03 09 2020
Historique:
received:
09
12
2019
revised:
09
06
2020
accepted:
12
06
2020
pubmed:
17
7
2020
medline:
28
4
2021
entrez:
17
7
2020
Statut:
ppublish
Résumé
While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of the functions involves interorgan communication with metabolic organs, such as the liver, through BAT-derived secretory factors, a.k.a., batokine. However, the identity and the roles of such mediators remain insufficiently understood. Here, we employed proteomics and transcriptomics in human thermogenic adipocytes and identified previously unappreciated batokines, including phospholipid transfer protein (PLTP). We found that increased circulating levels of PLTP, via systemic or BAT-specific overexpression, significantly improve glucose tolerance and insulin sensitivity, increased energy expenditure, and decrease the circulating levels of cholesterol, phospholipids, and sphingolipids. Such changes were accompanied by increased bile acids in the circulation, which in turn enhances glucose uptake and thermogenesis in BAT. Our data suggest that PLTP is a batokine that contributes to the regulation of systemic glucose and lipid homeostasis as a mediator of BAT-liver interorgan communication.
Identifiants
pubmed: 32672883
doi: 10.15252/embr.201949828
pmc: PMC7507062
doi:
Substances chimiques
Lipids
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e49828Subventions
Organisme : Edward Mallinckrodt, Jr. Foundation (EMF)
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK108822
Pays : United States
Organisme : Japan Society for the Promotion of Science London (JSPS London)
Pays : International
Organisme : NCRR NIH HHS
ID : M01 RR001271
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK098722
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : Sao Paulo Research Foundation
ID : 2016/03682-3
Pays : International
Organisme : Manpei Suzuki Diabetes Foundation
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK097441
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125281
Pays : United States
Informations de copyright
© 2020 The Authors.
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