Curcumin downregulates Smad pathways and reduces hepatic stellate cells activation in experimental fibrosis.
Animals
Anti-Inflammatory Agents
/ pharmacology
Antioxidants
/ pharmacology
Carbon Tetrachloride
Cell Transdifferentiation
/ drug effects
Chemical and Drug Induced Liver Injury
/ etiology
Curcumin
/ pharmacology
Cytokines
/ metabolism
Hepatic Stellate Cells
/ drug effects
Liver
/ drug effects
Liver Cirrhosis, Experimental
/ chemically induced
Male
Oxidative Stress
/ drug effects
Phosphorylation
Protective Agents
/ pharmacology
Rats, Wistar
Signal Transduction
Smad3 Protein
/ metabolism
Smad7 Protein
/ metabolism
CCl(4)
Curcumin
Fibrosis
HSC.
Smad
TGF-β
Journal
Annals of hepatology
ISSN: 1665-2681
Titre abrégé: Ann Hepatol
Pays: Mexico
ID NLM: 101155885
Informations de publication
Date de publication:
Historique:
received:
02
03
2020
revised:
06
05
2020
accepted:
28
05
2020
pubmed:
17
7
2020
medline:
24
8
2021
entrez:
17
7
2020
Statut:
ppublish
Résumé
Curcumin, a polyphenol, is a natural compound that has been widely studied as a hepatoprotector; however, only a few studies have examined its ability to reduce fibrosis in previously established cirrhosis. The objective of this study was to investigate whether curcumin could reduce carbon tetrachloride (CCl CCl Curcumin reduced liver damage, oxidative stress, fibrosis, and restored normal activity of MMP-9 and MMP-2. Besides, curcumin restored NF-κB, IL-1, IL-10, TGF-β, CTGF, Col-I, MMP-13, and Smad7 protein levels. On the other hand, curcumin decreased JNK and Smad3 phosphorylation. Furthermore, curcumin treatment decreased α-SMA and Smad3 protein and mRNA levels. Curcumin normalized GSH, and NF-κB, JNK-Smad3, and TGF-β-Smad3 pathways, leading to a decrement in activated hepatic stellate cells, thereby producing its antifibrotic effects.
Identifiants
pubmed: 32673649
pii: S1665-2681(20)30065-X
doi: 10.1016/j.aohep.2020.05.006
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Cytokines
0
Protective Agents
0
Smad3 Protein
0
Smad3 protein, rat
0
Smad7 Protein
0
Smad7 protein, rat
0
Carbon Tetrachloride
CL2T97X0V0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
497-506Informations de copyright
Copyright © 2020 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.