Small-cavity chamber dose response in megavoltage photon beams coupled to magnetic fields.

In MRgRT, dosimetry measurements are performed in the presence of magnetic fields. For high-resolution measurements, small-cavity ionization chambers are required. While Monte Carlo simulations are essential to determine dosimetry correction factors, models of small-chambers require careful validation with experimental measurements. The aim of this study is to characterize small-cavity chamber response coupled to magnetic fields. Small-cavity chambers (PTW31010, PTW31016, PTW31021 and PTW3022) are irradiated by a 6 MV photon beam for 9 magnetic field strengths between -1.5 T and +1.5 T. The chamber axis is orientated either parallel or perpendicular to the irradiation beam, with the magnetic field always perpendicular to the beam. MC simulations are performed in EGSnrc. The sensitive volume of the chambers is reduced to account for the inefficiency adjacent to the guard electrode (dead volume) based on COMSOL calculations of electric potentials. The magnetic field affects the chamber response by up to 4.1% and 4.5% in the parallel and perpendicular orientations, respectively, compared to no magnetic field. The maximal difference in dose response between experiments and simulations is up to 6.1% and 4.5% for parallel and perpendicular orientation, respectively. When the dead volume is removed, which accounts for the 15%-23% of the nominal volume, the difference, in most cases, is within the stated uncertainties. Nevertheless, for a particular chamber, the reduced nominal volume barely improved the agreement between the experimental and calculated relative response (4.53% to 4.13%). This disagreement may be due to the imperfect chamber geometry model, as was found from microCT images. A detailed uncertainty analysis is presented. The characterization of small-cavity ion chamber response coupled to magnetic fields is complex. Small differences between real and model chamber geometry that normally would be insignificant become an issue in the presence of magnetic fields. Accurate characterization of the nominal volume is essential for small-cavity ion chamber modelling.