Multitracer model for staging cortical amyloid deposition using PET imaging.

Aged Alzheimer Disease / diagnostic imaging Amyloidosis / diagnostic imaging Carbon Radioisotopes Cerebral Cortex / diagnostic imaging Cognitive Dysfunction / diagnostic imaging Cohort Studies Female Fluorine Radioisotopes Humans Longitudinal Studies Male Middle Aged Positron-Emission Tomography / methods

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
15 09 2020
Historique:
received: 09 09 2019
accepted: 20 03 2020
pubmed: 18 7 2020
medline: 5 11 2020
entrez: 18 7 2020
Statut: ppublish

Résumé

To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) from 6 cohorts (European Medical Information Framework for AD, Alzheimer's and Family, Alzheimer's Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3, Alzheimer's Disease Neuroimaging Initiative [ADNI]) who underwent amyloid PET were retrospectively included; 1,049 individuals had follow-up scans. With application of dataset-specific cutoffs to global standard uptake value ratio (SUVr) values from 27 regions, single-tracer and pooled multitracer regional rankings were constructed from the frequency of abnormality across 400 CU individuals (100 per tracer). The pooled multitracer ranking was used to create a staging model consisting of 4 clusters of regions because it displayed a high and consistent correlation with each single-tracer ranking. Relationships between amyloid stage, clinical variables, and longitudinal cognitive decline were investigated. SUVr abnormality was most frequently observed in cingulate, followed by orbitofrontal, precuneal, and insular cortices and then the associative, temporal, and occipital regions. Abnormal amyloid levels based on binary global SUVr classification were observed in 1.0%, 5.5%, 17.9%, 90.0%, and 100.0% of individuals in stage 0 to 4, respectively. Baseline stage predicted decline in Mini-Mental State Examination (MMSE) score (ADNI: n = 867, The pooled multitracer staging model successfully classified the level of amyloid burden in >3,000 individuals across cohorts and radiotracers and detects preglobal amyloid burden and distinct risk profiles of cognitive decline within globally amyloid-positive individuals.

Identifiants

DOI: 10.1212/WNL.0000000000010256 PMID: 32675080 PMC: PMC7713745
pubmed: 32675080
pii: WNL.0000000000010256
doi: 10.1212/WNL.0000000000010256
pmc: PMC7713745
doi:

Substances chimiques

Carbon Radioisotopes 0
Fluorine Radioisotopes 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1538-e1553

Subventions

Organisme : NIA NIH HHS
ID : R01 AG043434
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB009352
Pays : United States
Organisme : CIHR
Pays : Canada

Investigateurs

Eider M Arenaza-Urquijo (EM)
Annabella Beteta (A)
Anna Brugulat-Serrat (A)
Raffaele Cacciaglia (R)
Alba Cañas Boccagni (AC)
Yelena G Bodien (YG)
Marta Crous-Bou (M)
Carme Deulofeu (C)
Ruth Dominguez (R)
Karine Fauria (K)
Carles Falcon (C)
Marta Félez-Sánchez (M)
Jose María González de Echavarri (JM)
Oriol Grau-Rivera (O)
Laura Hernández (L)
Gema Huesa (G)
Jordi Huguet (J)
MarÍa LeÓn (M)
Paula Marne (P)
Tania Menchón (T)
Marta Milà-Alomà (M)
Grégory Operto (G)
Carolina Minguillon (C)
Maria Pascual (M)
Albina Polo (A)
Sandra Pradas (S)
Aleix Sala-Vila (A)
Gonzalo Sánchez-Benavides (G)
Mahnaz Shekari (M)
Anna Soteras (A)
Marc Suárez-Calvet (M)
Laia Tenas (L)
Marc Vilanova (M)
Natalia Vilor-Tejedor (N)
Frederik Barkhof (F)
Gill Farrar (G)
Carlos Diaz (C)
Sandra Pla (S)
Juan Domingo Gispert (JD)
Chris Buckley (C)
Giovanni Battista Frisoni (GB)
Andrew Stephens (A)
José Luis Molinuevo (JL)
Lisa Ford (L)
Mark Schmidt (M)
Isadora Lopes Alves (I)
Jean Georges (J)
Anja Mett (A)
Edo Richard (E)
Philip Scheltens (P)
Pieter Jelle Visser (PJ)
Bart NM van Berckel (BN)
Hans Berkhof (H)
Alle Meije Wink (A)
Maqsood Yaqub (M)
Annebet Leeuwis (A)
Ingrid van Maurik (I)
Lyduine Collij (L)
Fiona Heeman (F)
Ifrah Iidow (I)
Valentina Garibotto (V)
Daniele Altomare (D)
Christian Moro (C)
Craig Ritchie (C)
Graciela Muniz Terrera (G)
Catriona Wimberley (C)
Gerard Thompson (G)
Adam Waldman (A)
Pierre Payoux (P)
Bruno Vellas (B)
Julien Delrieu (J)
Laure Saint-Aubert (L)
Anne Hitzel (A)
Anne Julian (A)
Oriol Grau Rivera (OG)
Gemma Salvadó Blasco (G)
Mahnaz Shekari (M)
Iva Knezevic (I)
Andres Perissinotti (A)
Agneta Nordberg (A)
Miia Kivipelto (M)
Elena Rodriguez-Vieitez (E)
Irina Savitcheva (I)
Alexander Drzezga (A)
Frank Jessen (F)
Markus Dietlein (M)
Carsten Kobe (C)
Matthias Schmidt (M)
Zuzana Walker (Z)
Pawel Markiewicz (P)
Jieqing Jiao (J)
Zarni Win (Z)
Rossella Gismondi (R)
Nigel Banton (N)
Santiago Bullich (S)
Nikolay Manyakov (N)
Dzmitry Kaliukhovich (D)
Robin Wolz (R)
John Woodside (J)
Katherine Gray (K)
Cindy Birck (C)
Richard Milne (R)
Marthe Smedinga (M)

Informations de copyright

Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Lyduine E Collij (LE)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Fiona Heeman (F)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0001-7769-8329

Gemma Salvadó (G)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Silvia Ingala (S)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Daniele Altomare (D)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Arno de Wilde (A)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Elles Konijnenberg (E)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Marieke van Buchem (M)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Maqsood Yaqub (M)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0003-2122-740X

Pawel Markiewicz (P)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Sandeep S V Golla (SSV)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Viktor Wottschel (V)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0002-2902-2268

Alle Meije Wink (AM)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0002-8197-0118

Pieter Jelle Visser (PJ)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Charlotte E Teunissen (CE)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Adriaan A Lammertsma (AA)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Philip Scheltens (P)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0002-1046-6408

Wiesje M van der Flier (WM)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0001-8766-6224

Ronald Boellaard (R)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Bart N M van Berckel (BNM)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

José Luis Molinuevo (JL)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Juan Domingo Gispert (JD)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0002-6155-0642

Mark E Schmidt (ME)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.

Frederik Barkhof (F)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium.
ORCID: 0000-0003-3543-3706

Isadora Lopes Alves (I)

From Department of Radiology and Nuclear Medicine (L.E.C., F.H., S.I., M.Y., S.S.V.G., V.W., A.M.W., A.A.L., R.B., B.N.M.v.B., F.B., I.L.A.), Neurochemistry Laboratory (C.E.T.), Alzheimer Center (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), and Department of Neurology (D.A., A.d.W., E.K., M.v.B., P.J.V., P.S., W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, Netherlands; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation (G.S., J.L.M., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (J.D.G.); Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (J.L.M.), Madrid; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.L.M., J.D.G.), Barcelona; Universitat Pompeu Fabra (J.L.M., J.D.G.), Barcelona, Spain; Laboratory of Neuroimaging of Aging (D.A.), University of Geneva; Memory Clinic (D.A.), University Hospital of Geneva, Switzerland; Centre for Medical Image Computing (P.M., F.B.), Medical Physics and Biomedical Engineering, University College London, London, UK; and Janssen Pharmaceutica NV (M.E.S.), Beerse, Belgium. i.lopesalves@amsterdamumc.nl.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Amyloïdose › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Multitracer model for staging cortical amyloid...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Multitracer model for staging cortical amyloid...