Combining neurofeedback with source estimation: Evaluation of an sLORETA neurofeedback protocol for chronic tinnitus treatment.
EEG
Tinnitus
alpha
delta
neurofeedback
sLORETA
tomographic
Journal
Restorative neurology and neuroscience
ISSN: 1878-3627
Titre abrégé: Restor Neurol Neurosci
Pays: Netherlands
ID NLM: 9005499
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
18
7
2020
medline:
28
7
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Alpha/delta neurofeedback has been shown to be a potential treatment option for chronic subjective tinnitus. Traditional neurofeedback approaches working with a handful of surface electrodes have been criticized, however, due to their low spatial specificity. The purpose of this study was to evaluate an innovative tomographic neurofeedback protocol that combines neural activity measured across the whole scalp with sLORETA source estimation. Forty-eight tinnitus patients participated in 15 neurofeedback training sessions as well as extensive pre, post, and follow-up testing. Patients were randomly assigned to either a tomographic (TONF) or a traditional electrode-based neurofeedback (NTNF) group. Main outcome measures of this study were defined as tinnitus-related distress measured with the Tinnitus Handicap Inventory (THI) and Tinnitus Questionnaire (TQ), tinnitus loudness, and resting-state EEG activity in trained frequency bands. For both groups a significant reduction of tinnitus-related distress and tinnitus loudness was found. While distress changes remained persistent irrespective of group, loudness levels returned to baseline in the follow-up period. No significant between-group differences between the 2 neurofeedback applications (TONF vs. NTNF) were found, which suggests a similar contribution to symptom improvement. The trained alpha/delta ratio increased significantly over the course of the training and remained stable in the follow-up period. This effect was found irrespective of group on both surface and source levels with no meaningful differences between the 2 groups. Our study shows that a tomographic alpha/delta protocol should be considered a promising addition to tinnitus treatment but that more individually specific neurofeedback protocols should be developed.
Sections du résumé
BACKGROUND
Alpha/delta neurofeedback has been shown to be a potential treatment option for chronic subjective tinnitus. Traditional neurofeedback approaches working with a handful of surface electrodes have been criticized, however, due to their low spatial specificity.
OBJECTIVE
The purpose of this study was to evaluate an innovative tomographic neurofeedback protocol that combines neural activity measured across the whole scalp with sLORETA source estimation.
METHODS
Forty-eight tinnitus patients participated in 15 neurofeedback training sessions as well as extensive pre, post, and follow-up testing. Patients were randomly assigned to either a tomographic (TONF) or a traditional electrode-based neurofeedback (NTNF) group. Main outcome measures of this study were defined as tinnitus-related distress measured with the Tinnitus Handicap Inventory (THI) and Tinnitus Questionnaire (TQ), tinnitus loudness, and resting-state EEG activity in trained frequency bands.
RESULTS
For both groups a significant reduction of tinnitus-related distress and tinnitus loudness was found. While distress changes remained persistent irrespective of group, loudness levels returned to baseline in the follow-up period. No significant between-group differences between the 2 neurofeedback applications (TONF vs. NTNF) were found, which suggests a similar contribution to symptom improvement. The trained alpha/delta ratio increased significantly over the course of the training and remained stable in the follow-up period. This effect was found irrespective of group on both surface and source levels with no meaningful differences between the 2 groups.
CONCLUSIONS
Our study shows that a tomographic alpha/delta protocol should be considered a promising addition to tinnitus treatment but that more individually specific neurofeedback protocols should be developed.
Identifiants
pubmed: 32675432
pii: RNN200992
doi: 10.3233/RNN-200992
pmc: PMC7592665
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-299Références
Otolaryngol Head Neck Surg. 2011 Aug;145(2):282-7
pubmed: 21493265
BMC Med Inform Decis Mak. 2010 Aug 03;10:42
pubmed: 20682024
BMC Biol. 2008 Jan 16;6:4
pubmed: 18199318
Neurosci Lett. 2006 Feb 20;394(3):216-21
pubmed: 16343769
J Psychosom Res. 2012 Aug;73(2):112-21
pubmed: 22789414
Neurosci Lett. 2007 Oct 9;426(1):23-8
pubmed: 17888572
Clin Neurophysiol. 2004 Oct;115(10):2195-222
pubmed: 15351361
Prog Brain Res. 2007;166:525-36
pubmed: 17956816
PLoS Med. 2005 Jun;2(6):e153
pubmed: 15971936
Trends Cogn Sci. 2015 Oct;19(10):567-578
pubmed: 26412095
J Am Acad Audiol. 1998 Apr;9(2):153-60
pubmed: 9564679
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8075-80
pubmed: 21502503
Ear Hear. 2012 Mar-Apr;33(2):153-76
pubmed: 22156949
Neurosci Lett. 2009 Apr 10;453(3):225-8
pubmed: 19429040
Neural Plast. 2019 Mar 26;2019:3540898
pubmed: 31049052
HNO. 1994 Mar;42(3):166-72
pubmed: 8175381
Neuroimage. 2010 Aug 15;52(2):470-80
pubmed: 20417285
Int J Audiol. 2018 Jul;57(7):553-557
pubmed: 29490515
Front Neurol. 2017 Apr 03;8:115
pubmed: 28421030
Otolaryngol Clin North Am. 2003 Apr;36(2):239-48
pubmed: 12856294
Health Qual Life Outcomes. 2017 May 5;15(1):94
pubmed: 28476163
Hear Res. 2016 Dec;342:1-12
pubmed: 27671157
Auris Nasus Larynx. 2011 Dec;38(6):735-8
pubmed: 21592701
IEEE Trans Biomed Eng. 1997 Sep;44(9):867-80
pubmed: 9282479
J Speech Lang Hear Res. 2005 Oct;48(5):1204-35
pubmed: 16411806
World J Biol Psychiatry. 2011 Oct;12(7):489-500
pubmed: 21568629
Brain Topogr. 2014 Jan;27(1):149-57
pubmed: 23700271
Int J Psychophysiol. 1994 Oct;18(1):49-65
pubmed: 7876038
Brain Res. 2017 May 15;1663:194-204
pubmed: 28315312
Neurobiol Stress. 2016 Nov 30;8:211-224
pubmed: 29888315
BMC Complement Altern Med. 2012 Nov 28;12:235
pubmed: 23186556
Otolaryngol Head Neck Surg. 2007 Oct;137(4):589-95
pubmed: 17903575
Clin Neurophysiol. 2001 Apr;112(4):713-9
pubmed: 11275545
Front Behav Neurosci. 2014 Oct 22;8:373
pubmed: 25374520
J Child Psychol Psychiatry. 2009 Jul;50(7):780-9
pubmed: 19207632
Front Hum Neurosci. 2017 Mar 31;11:135
pubmed: 28408873
Biom J. 2008 Jun;50(3):346-63
pubmed: 18481363
J Neurosci. 2007 Feb 7;27(6):1479-84
pubmed: 17287523
Eur Child Adolesc Psychiatry. 2019 Mar;28(3):293-305
pubmed: 29445867
Otolaryngol Clin North Am. 2003 Apr;36(2):383-8
pubmed: 12856305
Trends Neurosci. 2016 Dec;39(12):799-812
pubmed: 27871729
Prog Brain Res. 2007;166:61-70
pubmed: 17956772
Trials. 2020 May 5;21(1):382
pubmed: 32370767
Electroencephalogr Clin Neurophysiol. 1995 Jan;94(1):26-40
pubmed: 7530637
IEEE Trans Neural Syst Rehabil Eng. 2004 Dec;12(4):387-97
pubmed: 15614994
Lancet Neurol. 2013 Sep;12(9):920-930
pubmed: 23948178
Neuroimage. 2007 Feb 15;34(4):1600-11
pubmed: 17207640
Front Neurol. 2015 Jun 09;6:124
pubmed: 26106362
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15222-7
pubmed: 10611366
Clin EEG Neurosci. 2009 Jul;40(3):180-9
pubmed: 19715181
Brain Behav. 2015 May;5(5):e00331
pubmed: 25874164
Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:5-12
pubmed: 12575463
Biofeedback Self Regul. 1995 Mar;20(1):83-99
pubmed: 7786929
Neurosci Biobehav Rev. 2014 Jul;44:16-32
pubmed: 23597755
Neuron. 2010 Jun 24;66(6):819-26
pubmed: 20620868
Restor Neurol Neurosci. 2007;25(3-4):371-8
pubmed: 17943012
Clin Neurophysiol. 2002 May;113(5):702-12
pubmed: 11976050
Hear Res. 2016 Apr;334:37-48
pubmed: 26415997
Hear Res. 2009 Jul;253(1-2):15-31
pubmed: 19364527
Front Aging Neurosci. 2017 Dec 01;9:386
pubmed: 29249959
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499
Int J Neurosci. 2007 Mar;117(3):337-57
pubmed: 17365119