ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib.

Circulating tumor DNA (ctDNA) epidermal growth factor receptor (EGFR) non-small-cell lung cancer (NSCLC) osimertinib

Journal

Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875

Informations de publication

Date de publication:
Jun 2020
Historique:
entrez: 18 7 2020
pubmed: 18 7 2020
medline: 18 7 2020
Statut: ppublish

Résumé

Several clinical trials have demonstrated the efficacy and safety of osimertinib in advanced non-small-cell lung cancer (NSCLC). However, there is significant unexplained variability in treatment outcome. Observational prospective cohort of 22 pre-treated patients with stage IV NSCLC harboring the epidermal growth factor receptor ( The median progression-free survival (PFS), since the start of osimertinib, was 8.9 [interquartile range (IQR): 4.6-18.0] months. The median treatment durations of sequential gefitinib + osimertinib, afatinib + osimertinib and erlotinib + osimertinib treatments were 30.1, 24.6 and 21.1 months, respectively. The p.T790M mutation was detected in 19 (86%) pre-treatment blood samples. Undetectable levels of the original Different molecular patterns identified by plasma genotyping may be of prognostic significance, suggesting that the use of liquid biopsy is a valuable approach for tumor monitoring.

Sections du résumé

BACKGROUND BACKGROUND
Several clinical trials have demonstrated the efficacy and safety of osimertinib in advanced non-small-cell lung cancer (NSCLC). However, there is significant unexplained variability in treatment outcome.
METHODS METHODS
Observational prospective cohort of 22 pre-treated patients with stage IV NSCLC harboring the epidermal growth factor receptor (
RESULTS RESULTS
The median progression-free survival (PFS), since the start of osimertinib, was 8.9 [interquartile range (IQR): 4.6-18.0] months. The median treatment durations of sequential gefitinib + osimertinib, afatinib + osimertinib and erlotinib + osimertinib treatments were 30.1, 24.6 and 21.1 months, respectively. The p.T790M mutation was detected in 19 (86%) pre-treatment blood samples. Undetectable levels of the original
CONCLUSIONS CONCLUSIONS
Different molecular patterns identified by plasma genotyping may be of prognostic significance, suggesting that the use of liquid biopsy is a valuable approach for tumor monitoring.

Identifiants

pubmed: 32676317
doi: 10.21037/tlcr.2020.04.01
pii: tlcr-09-03-532
pmc: PMC7354150
doi:

Types de publication

Journal Article

Langues

eng

Pagination

532-540

Informations de copyright

2020 Translational Lung Cancer Research. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/ tlcr.2020.04.01). AR reports other from Boehringer, Takeda during the conduct of the study. VC reports other from Roche, BMS, MSD, Pfizer, Lilly, AstraZeneca, Boehringer, Novartis, Takeda during the conduct of the study. MP reports other from Roche, BMS, MSD, Pfizer, Lilly, grants and other from AstraZeneca, Boehringer, other from Novartis, Takeda during the conduct of the study. MP serves as an unpaid editorial board member of Translational Lung Cancer Research from Sep 2019 to Sep 2021. The other authors have no conflicts of interest to declare.

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Auteurs

Atocha Romero (A)

Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Roberto Serna-Blasco (R)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Cristina Alfaro (C)

Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Estela Sánchez-Herrero (E)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Miguel Barquín (M)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

María Carmen Turpin (MC)

School of Medicine, Universidad Francisco de Vitoria, Madrid, Spain.

Sofía Chico (S)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Sandra Sanz-Moreno (S)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Alejandro Rodrigez-Festa (A)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Raquel Laza-Briviesca (R)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Alberto Cruz-Bermudez (A)

Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Virginia Calvo (V)

Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Ana Royuela (A)

Biostatistics Unit, Idiphisa, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Mariano Provencio (M)

Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Molecular Oncology Laboratory, Biomedical Sciences Research Institute Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.

Classifications MeSH