A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19.
Journal
ChemRxiv : the preprint server for chemistry
ISSN: 2573-2293
Titre abrégé: ChemRxiv
Pays: United States
ID NLM: 101720906
Informations de publication
Date de publication:
02 Jul 2020
02 Jul 2020
Historique:
entrez:
18
7
2020
pubmed:
18
7
2020
medline:
18
7
2020
Statut:
epublish
Résumé
The global Coronavirus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and economic consequences. The risk of morbidity and mortality due to COVID-19 increases dramatically in the presence of co-existing medical conditions while the underlying mechanisms remain unclear. Furthermore, there are no proven effective therapies for COVID-19. This study aims to identify SARS-CoV-2 pathogenesis, diseases manifestations, and COVID-19 therapies using network medicine methodologies along with clinical and multi-omics observations. We incorporate SARS-CoV-2 virus-host protein-protein interactions, transcriptomics, and proteomics into the human interactome. Network proximity measure revealed underlying pathogenesis for broad COVID-19-associated manifestations. Multi-modal analyses of single-cell RNA-sequencing data showed that co-expression of
Identifiants
pubmed: 32676577
doi: 10.26434/chemrxiv.12579137
pii: 12579137
pmc: PMC7350981
doi:
Types de publication
Preprint
Langues
eng
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Competing interests: The authors declare that they have no conflict of interest. The content of this publication does not necessarily reflect the views of the Cleveland Clinic.
Références
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
BMJ. 1999 Jul 10;319(7202):90
pubmed: 10398630
Nucleic Acids Res. 2014 Jan;42(Database issue):D1098-106
pubmed: 24234439
mBio. 2013 Apr 30;4(3):e00165-13
pubmed: 23631916
Nat Cell Biol. 2007 Dec;9(12):1401-12
pubmed: 17994010
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975
pubmed: 32350134
EMBO J. 2020 May 18;39(10):e105114
pubmed: 32246845
Nat Commun. 2019 Jun 17;10(1):2666
pubmed: 31209254
Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93
pubmed: 24841273
J Natl Cancer Inst. 1959 Apr;22(4):719-48
pubmed: 13655060
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
Allergy Asthma Clin Immunol. 2014 Feb 05;10(1):8
pubmed: 24499171
N Engl J Med. 2020 Aug 6;383(6):590-592
pubmed: 32402155
Antimicrob Agents Chemother. 2020 Jun 23;64(7):
pubmed: 32366720
N Engl J Med. 2020 May 7;382(19):1787-1799
pubmed: 32187464
World J Gastroenterol. 2013 May 28;19(20):2979-84
pubmed: 23716977
Nat Commun. 2018 Jul 12;9(1):2691
pubmed: 30002366
Z Rheumatol. 1991;50 Suppl 1:3-6
pubmed: 1907059
Am J Hum Genet. 2019 May 2;104(5):861-878
pubmed: 31006514
Indian J Crit Care Med. 2016 Sep;20(9):518-25
pubmed: 27688627
Nucleic Acids Res. 2013 Jan;41(Database issue):D1228-33
pubmed: 23180781
Genes Immun. 2013 Jul-Aug;14(5):310-6
pubmed: 23615072
Biochem Biophys Res Commun. 2019 Nov 5;519(2):402-408
pubmed: 31521245
Nat Commun. 2019 Mar 13;10(1):1197
pubmed: 30867426
Ther Drug Monit. 2016 Oct;38(5):621-7
pubmed: 27465973
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219
pubmed: 32391667
Immunology. 2000 Nov;101(3):300-8
pubmed: 11106932
Sci Adv. 2020 Apr 15;6(16):eaaz7086
pubmed: 32494619
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Am J Respir Cell Mol Biol. 2002 Jun;26(6):641-4
pubmed: 12034561
Mol Cell. 2020 May 21;78(4):779-784.e5
pubmed: 32362314
Nat Rev Drug Discov. 2016 May;15(5):327-47
pubmed: 26868298
Nucleic Acids Res. 2014 Jan;42(Database issue):D1091-7
pubmed: 24203711
N Engl J Med. 2020 Jul 30;383(5):496-498
pubmed: 32348640
Gastroenterology. 2011 Aug;141(2):633-41
pubmed: 21684284
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
Nucleic Acids Res. 2016 Jan 4;44(D1):D7-19
pubmed: 26615191
Int J Clin Exp Med. 2015 Sep 15;8(9):15238-45
pubmed: 26629009
mSystems. 2019 Apr 9;4(2):
pubmed: 30984872
Cell. 2020 May 28;181(5):1016-1035.e19
pubmed: 32413319
Nat Commun. 2019 Aug 2;10(1):3476
pubmed: 31375661
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
Cell Discov. 2020 Mar 16;6:14
pubmed: 32194980
Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50
pubmed: 20952405
Chin Med J (Engl). 2009 Jun 20;122(12):1388-93
pubmed: 19567158
Am J Hum Genet. 2011 Jun 10;88(6):755-766
pubmed: 21664998
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Trends Mol Med. 2016 Nov;22(11):919-921
pubmed: 27692879
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D514-7
pubmed: 15608251
Mol Biol Evol. 2013 Feb;30(2):332-46
pubmed: 22977115
PLoS Comput Biol. 2020 Feb 26;16(2):e1007701
pubmed: 32101536
Nat Commun. 2019 Jan 10;10(1):120
pubmed: 30631056
Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7
pubmed: 21948594
Cell Tissue Res. 2017 Mar;367(3):481-493
pubmed: 28025703
J Allergy Clin Immunol. 2012 Feb;129(2):573-5, 575.e1-10
pubmed: 22070913
JCI Insight. 2019 Dec 19;4(24):
pubmed: 31714895
Mol Biol Evol. 2005 Jan;22(1):174-7
pubmed: 15371530
Antiviral Res. 2015 Aug;120:140-6
pubmed: 26086883
Am J Respir Crit Care Med. 2014 Dec 15;190(12):1363-72
pubmed: 25338189
J Immunol. 2015 Jul 15;195(2):643-50
pubmed: 26048149
Circulation. 2020 May 19;141(20):1648-1655
pubmed: 32200663
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Sci Transl Med. 2013 Jun 19;5(190):190ra79
pubmed: 23785035
Nucleic Acids Res. 2007 Jan;35(Database issue):D198-201
pubmed: 17145705
Hum Mutat. 2003 Jun;21(6):577-81
pubmed: 12754702
Mol Biol Evol. 2014 Aug;31(8):2156-69
pubmed: 24881052
Cell. 2019 Sep 5;178(6):1493-1508.e20
pubmed: 31474370
Methods Mol Biol. 2019;1878:243-261
pubmed: 30378081
Drugs. 2004;64(13):1433-64
pubmed: 15212560
Circ Res. 2016 Jan 22;118(2):352-66
pubmed: 26838319
Nucleic Acids Res. 2016 Jan 4;44(D1):D1069-74
pubmed: 26578601
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Stat Med. 2010 Dec 20;29(29):3046-67
pubmed: 20827667
PLoS Comput Biol. 2016 Sep 15;12(9):e1005074
pubmed: 27632082
Brief Bioinform. 2017 Jul 1;18(4):682-697
pubmed: 27296652
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Science. 2020 Jul 3;369(6499):50-54
pubmed: 32358202
N Engl J Med. 2020 May 21;382(21):2012-2022
pubmed: 32227758
J Autoimmun. 2020 Aug;112:102463
pubmed: 32303424
Nature. 2020 Jul;583(7816):469-472
pubmed: 32408336
Am J Respir Cell Mol Biol. 1993 Mar;8(3):334-9
pubmed: 8383511
Allergy. 2000;55 Suppl 61:27-30
pubmed: 10919502
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
J Hum Genet. 2006;51(4):284-291
pubmed: 16432636
J Cell Physiol. 2020 Mar;235(3):2847-2856
pubmed: 31535369
Cell. 2020 Jul 9;182(1):59-72.e15
pubmed: 32492406
Clin Gastroenterol Hepatol. 2020 Jul;18(8):1663-1672
pubmed: 32278065
J Immunol. 2013 Apr 15;190(8):3949-58
pubmed: 23487427
Circ Res. 2020 Jun 5;126(12):1671-1681
pubmed: 32302265
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
PLoS One. 2018 Mar 22;13(3):e0194868
pubmed: 29566060
Am J Hum Genet. 2007 Jun;80(6):1103-14
pubmed: 17503328
Science. 2006 Sep 29;313(5795):1929-35
pubmed: 17008526
Immunology. 2007 Apr;120(4):435-46
pubmed: 17313487
BMC Infect Dis. 2019 Nov 12;19(1):968
pubmed: 31718563
BMC Immunol. 2005 Jan 18;6:2
pubmed: 15655079
Gastroenterology. 2020 May;158(6):1831-1833.e3
pubmed: 32142773
Am J Respir Crit Care Med. 2019 Oct 1;200(7):837-856
pubmed: 31161938
Proc Natl Acad Sci U S A. 2021 May 11;118(19):
pubmed: 33906951