Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study.
ARDS
COVID-19
Physiological dead-space
Ventilatory ratio
Journal
Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873
Informations de publication
Date de publication:
16 Jul 2020
16 Jul 2020
Historique:
received:
28
05
2020
accepted:
08
07
2020
entrez:
18
7
2020
pubmed:
18
7
2020
medline:
18
7
2020
Statut:
epublish
Résumé
COVID-19 ARDS could differ from typical forms of the syndrome. Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics. Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1-4] day after intubation (median [IQR]). Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1-44.7] mL/cmH We observed early in the course of COVID-19 ARDS high V
Identifiants
pubmed: 32676824
doi: 10.1186/s13613-020-00716-1
pii: 10.1186/s13613-020-00716-1
pmc: PMC7364286
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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