Machine-Driven Chemoenzymatic Synthesis of Glycopeptide.
automation
chemoenzymatic synthesis
machine-driven
peptide synthesizer
silica resin
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
02 11 2020
02 11 2020
Historique:
received:
28
01
2020
revised:
18
06
2020
pubmed:
18
7
2020
medline:
30
3
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Historically, researchers have put considerable effort into developing automation systems to prepare natural biopolymers such as peptides and oligonucleotides. The availability of such mature systems has significantly advanced the development of natural science. Over the past twenty years, breakthroughs in automated synthesis of oligosaccharides have also been achieved. A machine-driven platform for glycopeptide synthesis by a reconstructed peptide synthesizer is described. The designed platform is based on the use of an amine-functionalized silica resin to facilitate the chemical synthesis of peptides in organic solvent as well as the enzymatic synthesis of glycan epitopes in the aqueous phase in a single reaction vessel. Both syntheses were performed by a peptide synthesizer in a semiautomated manner.
Identifiants
pubmed: 32677091
doi: 10.1002/anie.202001124
pmc: PMC7733604
mid: NIHMS1651438
doi:
Substances chimiques
Enzymes
0
Glycopeptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19825-19829Subventions
Organisme : NIGMS NIH HHS
ID : U01 GM116263
Pays : United States
Informations de copyright
© 2020 Wiley-VCH GmbH.
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