Retrospective Observational Study of Brain MRI Findings in Patients with Acute SARS-CoV-2 Infection and Neurologic Manifestations.
Acute Disease
Adult
Aged
Aged, 80 and over
Betacoronavirus
Brain
/ diagnostic imaging
COVID-19
Cerebrovascular Disorders
/ complications
Coronavirus Infections
/ complications
Cross-Sectional Studies
Female
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Pandemics
Pneumonia, Viral
/ complications
Retrospective Studies
SARS-CoV-2
Journal
Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
18
7
2020
medline:
1
12
2020
entrez:
18
7
2020
Statut:
ppublish
Résumé
Background This study provides a detailed imaging assessment in a large series of patients infected with coronavirus disease 2019 (COVID-19) and presenting with neurologic manifestations. Purpose To review the MRI findings associated with acute neurologic manifestations in patients with COVID-19. Materials and Methods This was a cross-sectional study conducted between March 23 and May 7, 2020, at the Pitié-Salpêtrière Hospital, a reference center for COVID-19 in the Paris area. Adult patients were included if they had a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with acute neurologic manifestations and referral for brain MRI. Patients with a prior history of neurologic disease were excluded. The characteristics and frequency of different MRI features were investigated. The findings were analyzed separately in patients in intensive care units (ICUs) and other departments (non-ICU). Results During the inclusion period, 1176 patients suspected of having COVID-19 were hospitalized. Of 308 patients with acute neurologic symptoms, 73 met the inclusion criteria and were included (23.7%): thirty-five patients were in the ICU (47.9%) and 38 were not (52.1%). The mean age was 58.5 years ± 15.6 [standard deviation], with a male predominance (65.8% vs 34.2%). Forty-three patients had abnormal MRI findings 2-4 weeks after symptom onset (58.9%), including 17 with acute ischemic infarct (23.3%), one with a deep venous thrombosis (1.4%), eight with multiple microhemorrhages (11.3%), 22 with perfusion abnormalities (47.7%), and three with restricted diffusion foci within the corpus callosum consistent with cytotoxic lesions of the corpus callosum (4.1%). Multifocal white matter-enhancing lesions were seen in four patients in the ICU (5%). Basal ganglia abnormalities were seen in four other patients (5%). Cerebrospinal fluid analyses were negative for SARS-CoV-2 in all patients tested (
Identifiants
pubmed: 32677875
doi: 10.1148/radiol.2020202422
pmc: PMC7370354
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E313-E323Investigateurs
Cecile Delorme
(C)
Jean-Christophe Corvol
(JC)
Jean-Yves Delattre
(JY)
Stephanie Carvalho
(S)
Sandrine Sagnes
(S)
Bruno Dubois
(B)
Vincent Navarro
(V)
Celine Louapre
(C)
Tanya Stojkovic
(T)
Ahmed Id Baih
(A)
Charlotte Rosso
(C)
David Grabli
(D)
Ana Zenovia Gales
(AZ)
Bruno Millet
(B)
Benjamin Rohaut
(B)
Eleonore Bayen
(E)
Sophie Du Pont
(S)
Gaelle Bruneteau
(G)
Stephane Lehericy
(S)
Danielle Seilhean
(D)
Alexandra Durr
(A)
Foudil Lamari
(F)
Marion Houot
(M)
Vanessa Batista Brochard
(V)
Sophie Du Pont
(S)
Catherine Lubetzki
(C)
Danielle Seilhean
(D)
Pascale Pradat-Diehl
(P)
Yves Samson
(Y)
Khe Hoang-Xuan
(K)
Bertrand Fontaine
(B)
Lionel Naccache
(L)
Philippe Fossati
(P)
Isabelle Arnulf
(I)
Alexandra Durr
(A)
Alexandre Carpentier
(A)
Stephane Lehericy
(S)
Nadya Pyatigorskaya
(N)
Yves Edel
(Y)
Philippe Thoumie
(P)
Gilberte Robain
(G)
Bertrand Degos
(B)
Tarek Sharshar
(T)
Nathalie Dzierzynski
(N)
Kiyoka Kinugawa Bourron
(K)
Ana Zenovia Gales
(AZ)
Stephanie Bombois
(S)
Mehdi Touat
(M)
Ahmed Id Baih
(A)
Nicolas Villain
(N)
David Grabli
(D)
Maria del Mar Amador
(M)
Bruneteau Gaelle
(B)
Louise-Laure Mariani
(LL)
Nicolas Mezouar
(N)
Sara Leder
(S)
Graziella Mangone
(G)
Aurelie Meneret
(A)
Andreas Hartmann
(A)
Clement Tarrano
(C)
David Bendetowicz
(D)
Pierre-François Pradat
(PF)
Michel Baulac
(M)
Sara Sambin
(S)
Phintip Pichit
(P)
Florence Chochon
(F)
Adele Hesters
(A)
Bastien Herlin
(B)
An Hung Nguyen
(AH)
Claire Ewenczyk
(C)
Giulia Coarelli
(G)
Anna Heinzmann
(A)
Esteban Munoz Musat
(E)
Timothee Lenglet
(T)
Lydia Chougar
(L)
Nathalia Shor
(N)
Sophie Demeret
(S)
Benjamin Rouhaut
(B)
Tal Seidel Malkinson
(T)
Albert Cao
(A)
Clemence Marois
(C)
Katarzyna Siuda-Krzywicka
(K)
Salimata Gassama
(S)
Loic Le Guennec
(L)
Jean-Yves Rotge
(JY)
Bertrand Saudreau
(B)
Bruno Millet
(B)
Philippe Fossati
(P)
Victor Pitron
(V)
Nassim Sarni
(N)
Nathalie Girault
(N)
Redwan Maatoug
(R)
Ana Zenovia Gales
(AZ)
Smaranda Leu
(S)
Eleonore Bayen
(E)
Lionel Thivard
(L)
Julien Mayaux
(J)
Elise Morawiec
(E)
Alexandre Demoule
(A)
Laure Bottin
(L)
Marion Yger
(M)
Gaelle Ouvrard
(G)
Rebecca Haddad
(R)
Haysam Salman
(H)
Armelle Rametti-Lacroux
(A)
Alize Chalançon
(A)
Anais Herve
(A)
Hugo Royer
(H)
Florence Beauzor
(F)
Valentine Maheo
(V)
Christelle Laganot
(C)
Marie Biet
(M)
Rania Hilab
(R)
Aurore Besnard
(A)
Meriem Bouguerra
(M)
Gwen Goudard
(G)
Saida Houairi
(S)
Saba Al-Youssef
(S)
Safia Said
(S)
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