Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity.
CD4+CD8αα+IELs
CD8αα+TCRαβ+IELs
CD8αβ+TCRαβ+ IELs and celiac disease
TCRγδ+ IELs
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
11
02
2020
accepted:
20
04
2020
pubmed:
18
7
2020
medline:
24
3
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Intestinal immune tolerance is essential for the immune system, as it prevents abnormal immune responses to large quantities of antigens from the intestinal lumen, such as antigens from commensal microorganisms, and avoids self-injury. Intestinal intraepithelial lymphocytes (IELs), a special group of mucosal T lymphocytes, play a significant role in intestinal immune tolerance. To accomplish this, IELs exhibit a high threshold of activation and low reactivity to most antigens from the intestinal lumen. In particular, CD8αα
Identifiants
pubmed: 32678936
doi: 10.1002/JLB.3RU0220-111
pmc: PMC7891415
doi:
Substances chimiques
CD8 Antigens
0
Receptors, Antigen, T-Cell, alpha-beta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
339-347Informations de copyright
© 2020 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology.
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