Pediatric Cancers among Alaska Native People.
Native American
cancer surveillance
childhood cancers
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
14
04
2020
revised:
24
06
2020
accepted:
09
07
2020
pubmed:
18
7
2020
medline:
29
1
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
To evaluate the descriptive epidemiology of pediatric cancers among Alaska Native people. We used data from the Alaska Native Tumor Registry, a population-based registry capturing cancer information among Alaska Native people 1969-present. Specifically, we examined all cases of cancer diagnosed among individuals ages 0-19 years. Cases were classified according to the International Classification of Childhood Cancers, 3rd edition (ICCC-3). We estimated incidence and distribution of cases by ICCC-3 cancer site, comparing between the time periods 1969-1996 and 1997-2016. We assessed 12-month and 5-year cause-specific survival, and examined differences over the time period, adjusted for age, sex, and ICCC-3 site. Incidence rates of pediatric cancers increased between 1969 and 1996 (n = 134) and 1997 and 2016 (n = 186) among Alaska Native people, from 139.8 in 1 000 000 (95% CI, 116.99-165.7) to 197.54 in 1 000 000 (95% CI, 170.1-228.1). Distribution of ICCC-3 sites differed between time periods (P < .0001). Finally, cancer survival was high; the 12-month survival probability from all ICCC-3 sites combined was 0.88 (95% CI, 0.84-0.92) and the 5-year survival probability was 0.76 (95% CI, 0.70-0.81) for 1969-2016. After adjusting for age, sex, and ICCC-3 site, we observed a 57% decrease in the risk of death when comparing Alaska Native pediatric cancer cases diagnosed in 1997-2016 with those diagnosed in 1969-1996. This information will be of value for our understanding of pediatric cancers among Indigenous peoples of the US, and will also be informative for clinicians providing care to this population.
Identifiants
pubmed: 32679200
pii: S0022-3476(20)30881-7
doi: 10.1016/j.jpeds.2020.07.036
pmc: PMC8108443
mid: NIHMS1612433
pii:
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
288-294.e1Subventions
Organisme : NICHD NIH HHS
ID : R01 HD089951
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD090875
Pays : United States
Organisme : NIH HHS
ID : UG1 OD024944
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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