The cutaneous and intestinal microbiome in psoriatic disease.
Autoimmunity
Inflammatory bowel disease
Microbiome
Psoriasis
Psoriatic arthritis
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
24
05
2020
revised:
04
07
2020
accepted:
08
07
2020
pubmed:
18
7
2020
medline:
18
5
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic immune-mediated inflammatory diseases of multifactorial etiology. In addition to genetic and environmental factors, evidence supports involvement of a dysregulated human microbiome in the pathogenesis of psoriatic disease. In particular, alterations in the composition of the microbiome, termed dysbiosis, can result in downstream proinflammatory effects in the gut, skin, and joints. Both the cutaneous and intestinal microbial populations are implicated in the pathogenesis of psoriatic disease, although exact mechanisms are unclear. Herein, we review the relationship between the human microbiome and psoriatic disease. Further insight into the functions of the microbiome may allow for greater understanding of inflammatory disease processes and identification of additional therapeutic targets.
Identifiants
pubmed: 32679247
pii: S1521-6616(20)30433-2
doi: 10.1016/j.clim.2020.108537
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108537Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.