Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy.
Alzheimer's disease
EEG
Epilepsy
Seizures
THY-Tau22
Tau
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
01
04
2020
revised:
20
05
2020
accepted:
05
06
2020
pubmed:
18
7
2020
medline:
30
6
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Epileptic seizures constitute a significant comorbidity of Alzheimer's disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis. Here, we sought to evaluate the potential role of tau pathology regarding seizure occurrence. To this end, we performed intra-hippocampal electroencephalogram (EEG) recordings and PTZ (pentylenetetrazol) seizure threshold tests in THY-Tau22 transgenic mice of AD-like tau pathology. We demonstrate that despite a lack of spontaneous epileptiform activity in Tau22 mice, the animals display increased PTZ-induced seizure susceptibility and mortality. The increased propensity for induced seizures in THY-Tau22 mutants correlates with astrogliosis and increased expression of adenosine kinase, consistent with increased network excitability. These data support an impact of tau pathology toward AD-associated seizures and suggest that tau pathology may contribute to seizure generation in AD independent of Aβ pathology.
Identifiants
pubmed: 32679397
pii: S0197-4580(20)30195-0
doi: 10.1016/j.neurobiolaging.2020.06.004
pmc: PMC7483348
mid: NIHMS1605843
pii:
doi:
Substances chimiques
tau Proteins
0
Pentylenetetrazole
WM5Z385K7T
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-270Subventions
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103740
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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