lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer.
CDKN1C
STEAP3
STEAP3-AS1
colon cancer
metallothionein
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
04 Sep 2020
04 Sep 2020
Historique:
received:
24
02
2020
revised:
01
06
2020
accepted:
15
06
2020
pubmed:
18
7
2020
medline:
18
7
2020
entrez:
18
7
2020
Statut:
ppublish
Résumé
Previous studies have reported that long noncoding RNAs (lncRNAs) have acted as new players during tumorigenesis. Metallothionein also plays an important role in tumor progression. It is mainly considered to be involved in the process of cell proliferation, oxidative stress, and multidrug resistance. However, the potential involvement of metallothionein-related lncRNAs in colon cancer remains poorly understood. In our study, we found that MT1M affected the expression of lncRNA STEAP3-AS1. STEAP3-AS1 is located in physical contiguity with STEAP3 and notably increased in colon cancer tissues and cell lines. STEAP3-AS1 expression was negatively associated with the expression of STEAP3. High levels of STEPA3-AS1 were associated with poor overall survival in colon cancer patients. In in vitro assays, STEAP3-AS1 knockdown could inhibit colon cancer cell proliferation and migration and arrest colon cancer cells at the G
Identifiants
pubmed: 32679543
pii: S2162-2531(20)30172-4
doi: 10.1016/j.omtn.2020.06.011
pmc: PMC7360886
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
480-491Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
Biochim Biophys Acta. 2011 Aug;1816(1):50-6
pubmed: 21447370
Science. 2005 Sep 2;309(5740):1564-6
pubmed: 16141073
Mol Cancer Res. 2012 May;10(5):573-87
pubmed: 22522456
Trends Biochem Sci. 2004 Feb;29(2):88-94
pubmed: 15102435
PLoS One. 2011 Apr 25;6(4):e18487
pubmed: 21541013
Cancer Lett. 2013 Oct 10;339(2):159-66
pubmed: 23791884
Cancer Cell. 2015 Oct 12;28(4):529-540
pubmed: 26461095
Blood. 2014 May 29;123(22):3429-39
pubmed: 24652995
Toxicology. 2011 May 10;283(2-3):65-87
pubmed: 21414382
Haematologica. 2012 Dec;97(12):1826-35
pubmed: 22689674
J Cell Biochem. 2004 Nov 1;93(4):664-71
pubmed: 15389973
BMC Cancer. 2018 Apr 16;18(1):430
pubmed: 29661169
J Cell Biochem. 2018 Sep;119(9):7696-7706
pubmed: 29923223
Oncology. 2001;61(2):162-7
pubmed: 11528256
Cancer Res. 2006 May 1;66(9):4795-801
pubmed: 16651434
Mol Carcinog. 2002 Jan;33(1):44-55
pubmed: 11807957
BMC Complement Altern Med. 2016 Aug 11;16(1):281
pubmed: 27514524
Genome Res. 2013 Sep;23(9):1446-61
pubmed: 23796952
Int J Mol Sci. 2015 Feb 03;16(2):3251-66
pubmed: 25654223
Hum Pathol. 2012 Feb;43(2):197-208
pubmed: 21820154
Free Radic Biol Med. 2012 Nov 1;53(9):1748-59
pubmed: 22960578
Mol Cancer. 2018 May 2;17(1):87
pubmed: 29720189
Pharmacol Ther. 2018 Mar;183:90-117
pubmed: 28987322
Cell. 1994 Jul 15;78(1):67-74
pubmed: 8033213
Hepatology. 2016 Mar;63(3):898-913
pubmed: 26606000
Hum Pathol. 2017 Feb;60:180-187
pubmed: 27825812
Exp Cell Res. 2011 Nov 1;317(18):2582-91
pubmed: 21871451
Mol Cancer. 2016 May 27;15(1):43
pubmed: 27233618
Cell Res. 2017 May;27(5):604-605
pubmed: 28290465
J Biol Chem. 2003 Nov 7;278(45):44255-64
pubmed: 12947099
Theranostics. 2017 Oct 17;7(19):4836-4849
pubmed: 29187907
J Trace Elem Med Biol. 2005;19(1):13-7
pubmed: 16240666
CA Cancer J Clin. 2019 Jan;69(1):50-79
pubmed: 30452086
Cell Discov. 2018 Jan 30;4:5
pubmed: 29507753
Cancer Res. 2000 Jan 15;60(2):262-5
pubmed: 10667572
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15231-6
pubmed: 15477587
Cell Physiol Biochem. 2017;44(2):567-580
pubmed: 29145177
Nat Biotechnol. 2003 Apr;21(4):379-86
pubmed: 12640466
J Hematol Oncol. 2018 Aug 23;11(1):107
pubmed: 30139373
FEBS Lett. 2011 Jan 21;585(2):421-8
pubmed: 21187089
Nat Struct Mol Biol. 2012 Nov;19(11):1068-75
pubmed: 23132386
Dev Cell. 2008 Feb;14(2):159-69
pubmed: 18267085
J Hematol Oncol. 2017 Jan 21;10(1):28
pubmed: 28109307
Metallomics. 2014 Jan;6(1):55-68
pubmed: 24068159
Autophagy. 2015;11(12):2184-98
pubmed: 26566051
Int J Oncol. 2003 Dec;23(6):1537-43
pubmed: 14612924
Lancet Oncol. 2017 Aug;18(8):e437
pubmed: 28648557
BMC Cancer. 2017 May 25;17(1):369
pubmed: 28545470
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2284-9
pubmed: 12606722
J Cell Physiol. 2020 May;235(5):4268-4278
pubmed: 31608996
Cell Signal. 2014 Dec;26(12):2961-8
pubmed: 25261601