Single-bite versus double-bite technique for mapping biopsies during endoscopic surveillance for hereditary diffuse gastric cancer: a single-center, randomized trial.
Journal
Endoscopy
ISSN: 1438-8812
Titre abrégé: Endoscopy
Pays: Germany
ID NLM: 0215166
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
pubmed:
18
7
2020
medline:
27
4
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
BACKGROUND : Endoscopic surveillance is recommended in patients with hereditary diffuse gastric cancer (HDGC) who refuse or want to delay surgery. Because early signet-ring cell carcinoma (SRCC) can be inconspicuous, the current surveillance endoscopy protocol entails 30 random biopsies, which are time-consuming. This study aimed to compare single-bite and double-bite techniques in HDGC surveillance. METHODS : Between October 2017 and December 2018, consecutive patients referred for HDGC surveillance were prospectively randomized to the single- or double-bite arm. The primary outcome was the diagnostic yield for SRCC foci. Secondary outcomes were: procedural time for random biopsies; comfort score; biopsy size; and quality of specimens, the latter assessed by the presence of muscularis mucosa, crush artifact, and proportion usable for diagnostic assessment. RESULTS : 25 patients were randomized to the single-bite arm and 23 to the double-bite arm. SRCC foci were detected in three and four patients in the single- and double-bite arms, respectively (
Identifiants
pubmed: 32679601
doi: 10.1055/a-1201-3125
pmc: PMC7116833
mid: EMS86657
doi:
Substances chimiques
Cadherins
0
Banques de données
ClinicalTrials.gov
['NCT03950908']
Types de publication
Clinical Trial
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
246-253Subventions
Organisme : Cancer Research UK
ID : A21102
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
Can J Gastroenterol. 2007 Mar;21(3):164-8
pubmed: 17377645
J Med Genet. 2015 Jun;52(6):361-74
pubmed: 25979631
Fam Cancer. 2016 Oct;15(4):665-76
pubmed: 27256430
Gastrointest Endosc. 2014 Jul;80(1):78-87
pubmed: 24472763
Gastroenterology. 2001 Dec;121(6):1348-53
pubmed: 11729114
Gut. 2004 Jun;53(6):775-8
pubmed: 15138199
Gastrointest Endosc. 2018 Feb;87(2):408-418
pubmed: 28688938
Gastrointest Endosc. 2001 Nov;54(5):600-4
pubmed: 11677476
Gastrointest Endosc. 2018 Feb;87(2):397-404.e2
pubmed: 28455161
J Med Genet. 2010 Jul;47(7):436-44
pubmed: 20591882
Gastrointest Endosc. 2015 May;81(5):1228-33
pubmed: 25638509
Gut. 2005 Apr;54(4):461-8
pubmed: 15753528
JAMA Oncol. 2015 Apr;1(1):23-32
pubmed: 26182300
Surg Oncol. 2011 Dec;20(4):e223-6
pubmed: 21872467
Gastrointest Endosc. 2003 Feb;57(2):170-3
pubmed: 12556778