Relationship of lymph node status with survival and recurrence among women with endometrial cancer.
Endometrial carcinoma
Lymph node
Lymph node count
Lymph node ratio
Prognosis
Recurrence
Survival
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
14
01
2020
revised:
08
05
2020
accepted:
14
07
2020
pubmed:
18
7
2020
medline:
30
12
2020
entrez:
18
7
2020
Statut:
ppublish
Résumé
To explore the relationship of lymph node ratio (LNR) and other lymph node parameters with disease-free (DFS) and overall (OS) survival among women with endometrial cancer. Retrospective analysis of data of women diagnosed with endometrial cancer at Hacettepe University Hospitals, Ankara, Turkey, between 2003 and 2013. Women who had their surgical procedure, pathology review, and follow-up at Hacettepe University Hospitals were included in the study. Receiver operator characteristic (ROC) curve analysis was used to determine the threshold LNR associated with survival. Overall, 376 women were included in the study. A higher number of excised metastatic lymph nodes was associated with decreased survival. ROC curve analysis determined a threshold LNR of 0.03. Women with LNR higher than 0.03 had decreased DFS (P<0.001) and OS (P<0.001) relative to those with LNR of 0.03 or lower. LNR of 0.1 was found to be a significant cutoff value for DFS (P=0.023) and OS (P=0.036) among women with at least one metastatic lymph node. LNR may be used as a prognostic tool in endometrial cancer. Future studies will help to define a precise threshold of LNR in order to implement this prognostic factor in daily practice.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
267-271Informations de copyright
© 2020 International Federation of Gynecology and Obstetrics.
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