Chemometric and Transcriptomic Profiling, Microtubule Disruption and Cell Death Induction by Secalonic Acid in Tumor Cells.
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Cell Cycle
/ drug effects
Cell Death
/ drug effects
Cell Line, Tumor
Gene Expression Profiling
/ methods
Humans
Leukemia
Metabolomics
/ methods
Microtubules
/ drug effects
Molecular Structure
Multiple Myeloma
Transcriptome
Xanthones
/ chemistry
cancer
drug resistance
microarray analysis
multiple myeloma
mycotoxins
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
15
06
2020
revised:
10
07
2020
accepted:
14
07
2020
entrez:
19
7
2020
pubmed:
19
7
2020
medline:
2
3
2021
Statut:
epublish
Résumé
Nature is an indispensable source of new drugs, providing unique bioactive lead structures for drug discovery. In the present study, secalonic acid F (SAF), a naturally occurring ergochrome pigment, was studied for its cytotoxicity against various leukemia and multiple myeloma cells by the resazurin assay. SAF exhibited cytotoxic activity on both leukemia and multiple myeloma cells. Generally, multiple myeloma cells were more sensitive to SAF than leukemia cells. NCI-H929 cells were the most affected cells among the tested panel of multiple myeloma cell lines and were taken for further studies to assess the mode of action of SAF on those cells. Cell cycle analysis revealed that SAF induced S and G2/M arrest in NCI-H929 cells. SAF-associated apoptosis and necrosis resulted in cytotoxicity. SAF further inclined the disassembly of the tubulin network, which may also account for its cytotoxicity. COMPARE and hierarchical cluster analyses of transcriptome-wide expression profiles of the NCI tumor cell line panel identified genes involved in numerous cellular processes (e.g., cell differentiation, cell migration, and other numerous signaling pathways) notably correlated with log
Identifiants
pubmed: 32679716
pii: molecules25143224
doi: 10.3390/molecules25143224
pmc: PMC7397039
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Xanthones
0
secalonic acid
56283-72-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutscher Akademischer Austauschdienst
ID : 57440917
Références
Pharmacogenet Genomics. 2009 Dec;19(12):979-83
pubmed: 21151855
Zhong Yao Cai. 2008 Jun;31(6):864-5
pubmed: 18998570
Am J Hematol. 2016 Jul;91(7):719-34
pubmed: 27291302
Blood. 2008 Mar 1;111(5):2521-6
pubmed: 17901246
Blood Cancer J. 2017 Jun 30;7(6):e577
pubmed: 28665419
Drugs Exp Clin Res. 1987;13(6):339-44
pubmed: 3652923
Molecules. 2019 Jan 22;24(3):
pubmed: 30678274
Neoplasma. 2017;64(3):344-350
pubmed: 28253713
Mar Drugs. 2015 Apr 03;13(4):2010-29
pubmed: 25854646
Prog Tumor Res. 2016;43:87-100
pubmed: 27595359
Nat Genet. 2000 Mar;24(3):227-35
pubmed: 10700174
J Nat Prod. 2016 Mar 25;79(3):629-61
pubmed: 26852623
Oncol Rep. 2012 Dec;28(6):2016-22
pubmed: 23023390
Magn Reson Chem. 2007 Sep;45(9):777-80
pubmed: 17619228
J Nat Med. 2020 Mar;74(2):495-500
pubmed: 32002808
Chem Pharm Bull (Tokyo). 1971 Jan;19(1):199-201
pubmed: 5544365
Gan. 1980 Dec;71(6):900-6
pubmed: 7274633
Blood. 2010 Jan 21;115(3):453-74
pubmed: 19880497
Lancet Oncol. 2014 Nov;15(12):e538-48
pubmed: 25439696
Phytomedicine. 2016 Jul 15;23(8):856-63
pubmed: 27288921
J Toxicol Environ Health. 1979 Nov;5(6):1159-69
pubmed: 529343
Food Chem Toxicol. 2019 Jan;123:522-535
pubmed: 30471312
Nat Genet. 2000 Mar;24(3):236-44
pubmed: 10700175
Front Pharmacol. 2018 Feb 26;9:136
pubmed: 29535628
Circ Res. 2016 Sep 30;119(8):896-9
pubmed: 27688305
Cancer Res. 1988 Feb 1;48(3):589-601
pubmed: 3335022
Chem Pharm Bull (Tokyo). 1974 Jul;22(7):1600-6
pubmed: 4434583
Semin Cell Dev Biol. 2011 Dec;22(9):968-74
pubmed: 22001384
Nat Rev Drug Discov. 2010 Oct;9(10):790-803
pubmed: 20885410
Biochem Pharmacol. 2013 Jun 1;85(11):1619-25
pubmed: 23583455
Cancer Chemother Pharmacol. 1983;11(3):144-6
pubmed: 6416694
Pharm Biol. 2011 Aug;49(8):796-9
pubmed: 21495809
Cancer. 2015 Aug 1;121(15):2517-28
pubmed: 25891003
J Org Chem. 1977 Jan 21;42(2):352-3
pubmed: 830866
Eur J Biochem. 2000 Sep;267(17):5421-6
pubmed: 10951200
Int J Hematol. 2016 Sep;104(3):271-2
pubmed: 27283410
Tetrahedron. 1970 Jan;26(1):51-7
pubmed: 5415401
Cancer Res. 2015 Jul 15;75(14):2886-96
pubmed: 25977334
Leukemia. 2014 May;28(5):1122-8
pubmed: 24157580
J Natl Cancer Inst. 1990 Jul 4;82(13):1113-8
pubmed: 2359137
Chemistry. 2008;14(16):4913-23
pubmed: 18425741
J Natl Cancer Inst. 1989 Jul 19;81(14):1088-92
pubmed: 2738938
Arch Pharm Res. 2006 Jan;29(1):59-63
pubmed: 16491844
Acta Pharm Sin B. 2019 May;9(3):516-525
pubmed: 31193763
N Engl J Med. 2011 Mar 17;364(11):1046-60
pubmed: 21410373
Science. 1998 Oct 23;282(5389):628-9
pubmed: 9841413
Future Cardiol. 2017 Jul;13(4):379-396
pubmed: 28660778
Cell Cycle. 2009 Aug;8(15):2444-50
pubmed: 19571678
Nat Rev Cancer. 2004 Apr;4(4):253-65
pubmed: 15057285
Oncol Rep. 2010 Feb;23(2):387-95
pubmed: 20043099