Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells.
AMP-Activated Protein Kinases
/ metabolism
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Autophagy
/ drug effects
Cell Line, Tumor
Dose-Response Relationship, Drug
Humans
Inhibitory Concentration 50
Mitochondria
/ drug effects
Neuroblastoma
/ drug therapy
Peptides, Cyclic
/ chemistry
Phosphorylation
Protein Conformation
Structure-Activity Relationship
TOR Serine-Threonine Kinases
/ metabolism
apoptosis
autophagy
biotransformation
cyanobacteria
laxaphycin
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
08
06
2020
revised:
06
07
2020
accepted:
13
07
2020
entrez:
19
7
2020
pubmed:
19
7
2020
medline:
19
5
2021
Statut:
epublish
Résumé
Laxaphycins are a family of non-ribosomal lipopeptides that have been isolated from several cyanobacteria. Some of these compounds have presented cytotoxic activities, but their mechanism of action is poorly understood. In this work, the already described laxaphycins B and B3, and acyclolaxaphycins B and B3 were isolated from the marine cyanobacteria
Identifiants
pubmed: 32679743
pii: md18070364
doi: 10.3390/md18070364
pmc: PMC7404270
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Laxaphycin B
0
Peptides, Cyclic
0
laxaphycin B3
0
MTOR protein, human
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia
ID : GRC GI-1682 (ED431C 2017/01)
Organisme : CDTI and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad
ID : AGL2016-78728-R (AEI/FEDER, UE), ISCIII/PI16/01830 and RTC-2016-5507-2, ITC-20161072
Organisme : European Union
ID : POCTEP 0161-Nanoeaters -1-E-1, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX
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