Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease.
drug release
local drug delivery systems
oral drug delivery systems (DDS)
periodontitis (PD), polymers
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
23
06
2020
revised:
13
07
2020
accepted:
14
07
2020
entrez:
19
7
2020
pubmed:
19
7
2020
medline:
19
7
2020
Statut:
epublish
Résumé
Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.
Identifiants
pubmed: 32679893
pii: polym12071574
doi: 10.3390/polym12071574
pmc: PMC7407295
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Horizon 2020 Framework Programme
ID : 01R16P00718
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