Methylmercury toxic mechanism related to protein degradation and chemokine transcription.
Chemokines
Methylmercury
Mitochondria
Pyruvate
Ubiquitin-proteasome pathway
Journal
Environmental health and preventive medicine
ISSN: 1347-4715
Titre abrégé: Environ Health Prev Med
Pays: Japan
ID NLM: 9609642
Informations de publication
Date de publication:
17 Jul 2020
17 Jul 2020
Historique:
received:
02
04
2020
accepted:
29
06
2020
entrez:
19
7
2020
pubmed:
19
7
2020
medline:
20
9
2020
Statut:
epublish
Résumé
Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
Identifiants
pubmed: 32680455
doi: 10.1186/s12199-020-00868-3
pii: 10.1186/s12199-020-00868-3
pmc: PMC7469908
doi:
Substances chimiques
Chemokines
0
Methylmercury Compounds
0
Neurotoxins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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