Neurologic and neuroimaging findings in patients with COVID-19: A retrospective multicenter study.
Adult
Aged
Aged, 80 and over
Betacoronavirus
Brain
/ diagnostic imaging
Brain Ischemia
/ diagnostic imaging
COVID-19
Confusion
/ physiopathology
Consciousness Disorders
/ physiopathology
Coronavirus Infections
/ diagnostic imaging
Encephalitis
/ diagnostic imaging
Female
France
Headache
/ physiopathology
Humans
Magnetic Resonance Imaging
Male
Meningitis
/ diagnostic imaging
Meningoencephalitis
/ diagnostic imaging
Middle Aged
Pandemics
Pneumonia, Viral
/ diagnostic imaging
Psychomotor Agitation
/ physiopathology
Pyramidal Tracts
/ diagnostic imaging
Respiratory Distress Syndrome
/ physiopathology
Retrospective Studies
SARS-CoV-2
Stroke
/ diagnostic imaging
Young Adult
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
29 09 2020
29 09 2020
Historique:
received:
28
04
2020
accepted:
09
06
2020
pubmed:
19
7
2020
medline:
9
10
2020
entrez:
19
7
2020
Statut:
ppublish
Résumé
To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI. The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal enhancement (17%), and encephalitis (13%) were the most frequent neuroimaging findings. Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). The profile of patients experiencing ischemic stroke was different from that of other patients with abnormal brain imaging: the former less frequently had acute respiratory distress syndrome ( Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. In terms of meningoencephalitis involvement, even if a direct effect of the virus cannot be excluded, the pathophysiology seems to involve an immune or inflammatory process given the presence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF. NCT04368390.
Identifiants
pubmed: 32680942
pii: WNL.0000000000010112
doi: 10.1212/WNL.0000000000010112
doi:
Banques de données
ClinicalTrials.gov
['NCT04368390']
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1868-e1882Commentaires et corrections
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Informations de copyright
© 2020 American Academy of Neurology.