Impregnation of healthy nail tissue with optical clearing agents for improved optical coherence tomography imaging.
caliper
crodamol
nail tissue
optical clearing agent
optical coherence tomography
Journal
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
ISSN: 1600-0846
Titre abrégé: Skin Res Technol
Pays: England
ID NLM: 9504453
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
18
05
2020
accepted:
20
06
2020
pubmed:
19
7
2020
medline:
19
8
2021
entrez:
19
7
2020
Statut:
ppublish
Résumé
The impact of optical tissue clearing on optical coherence tomography (OCT) for nail tissue imaging has not been investigated. This study seeks to compare the effects of an emollient and water on visualization of micromorphology and morphometric outcomes. Thirty-six healthy nail plates were processed with a fractional CO Emollient-impregnation caused stronger scatter responses (P < .0001) and decreased nail thickness (MD 45 μm, P < .0001) measured on OCT. Caliper-derived measurements were not affected by Crodamol™ (MD 11 μm, P = .5538). Hydration increased nail thickness on OCT (MD 49 μm, P < .0001) but reduced thickness measurements taken with calipers (MD 41 μm, P < .0001). Emollient-impregnation improved visualization of onychocytes compared with dry (P = .0209) and hydrated samples (P < .0001), and reduced occurrence of refractive artifacts (P < .0001). The use of an emollient for OCT imaging can enhance nail tissue visualization without significant effects on caliper measurements. Hydration of nails, in contrast with emollient-impregnation, may lead to disagreement between caliper- and OCT-measured nail thickness and should be practiced cautiously.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
178-182Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
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