Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms.

allogeneic hematopoietic cell transplantation antimicrobial resistance fecal microbiota transplant gut microbiome multidrug-resistant bacteria

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
26 04 2021
Historique:
received: 14 01 2020
accepted: 04 08 2020
pubmed: 19 7 2020
medline: 21 5 2021
entrez: 19 7 2020
Statut: ppublish

Résumé

Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.

Identifiants

pubmed: 32681643
pii: 5873448
doi: 10.1093/cid/ciaa948
pmc: PMC8075030
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1444-1447

Subventions

Organisme : Medical Research Council
ID : MR/P028225/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R000875/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T005254/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

Références

Gut. 2018 Nov;67(11):1920-1941
pubmed: 30154172
Nephrol Dial Transplant. 2017 Oct 1;32(10):1758-1766
pubmed: 28967964
Clin Infect Dis. 2018 Mar 19;66(7):e1-e48
pubmed: 29462280
Open Forum Infect Dis. 2015 Jun 03;2(2):ofv078
pubmed: 26180828
N Engl J Med. 2013 Jan 31;368(5):407-15
pubmed: 23323867
Open Forum Infect Dis. 2019 Jul 1;6(7):
pubmed: 31363779
Clin Microbiol Infect. 2019 Aug;25(8):958-963
pubmed: 30986562
Bone Marrow Transplant. 2017 Oct;52(10):1452-1454
pubmed: 28714946
Clin Infect Dis. 2016 Jun 15;62(12):1479-1486
pubmed: 27025836
Antimicrob Resist Infect Control. 2018 Aug 13;7:100
pubmed: 30123500
J Clin Microbiol. 2015 Jun;53(6):1986-9
pubmed: 25878340

Auteurs

Rohma Ghani (R)

Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Benjamin H Mullish (BH)

Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Department of Gastroenterology and Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

Julie A K McDonald (JAK)

Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.

Anan Ghazy (A)

Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Horace R T Williams (HRT)

Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Department of Gastroenterology and Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

Eimear T Brannigan (ET)

Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Siddharth Mookerjee (S)

Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Giovanni Satta (G)

Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Mark Gilchrist (M)

Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Neill Duncan (N)

Department of Renal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

Richard Corbett (R)

Department of Renal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

Andrew J Innes (AJ)

Centre for Haematology, Imperial College London, and Hammersmith Hospital, Imperial College London NHS Trust, London, United Kingdom.

Jiří Pavlů (J)

Centre for Haematology, Imperial College London, and Hammersmith Hospital, Imperial College London NHS Trust, London, United Kingdom.

Mark R Thursz (MR)

Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
Department of Gastroenterology and Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.

Frances Davies (F)

Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.

Julian R Marchesi (JR)

Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
School of Biosciences, Cardiff University, Cardiff, United Kingdom.

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Classifications MeSH