Indirect Determination of Amikacin by Gold Nanoparticles as Redox Probe.
Amikacin
antibutics
electrochemical sensor
gold nanoparticles
human serum.
voltammetry
Journal
Current drug delivery
ISSN: 1875-5704
Titre abrégé: Curr Drug Deliv
Pays: United Arab Emirates
ID NLM: 101208455
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
02
2020
revised:
16
03
2020
accepted:
25
04
2020
pubmed:
20
7
2020
medline:
3
11
2021
entrez:
20
7
2020
Statut:
ppublish
Résumé
Amikacin is an aminoglycoside antibiotic used for many gram-negative bacterial infections like infections in the urinary tract, infections in brain, lungs and abdomen. Electrochemical determination of amikacin is a challenge in electroanalysis because it shows no voltammetric peak at the surface of bare electrodes. In this approach, a very simple and easy method for indirect voltammetric determination of amikacin presented in real samples. Gold nanoparticles were electrodeposited at the surface of glassy carbon electrode in constant potential. The effect of several parameters such as time and potential of deposition, pH and scan rates on signal were studied. The cathodic peak current of Au Two dynamic linear ranges of 1.0 × 10 The method was successfully determined amikacin in pharmaceutical preparation and human serum. The effect of several interference in determination of amikacin was also studied.
Sections du résumé
BACKGROUND
BACKGROUND
Amikacin is an aminoglycoside antibiotic used for many gram-negative bacterial infections like infections in the urinary tract, infections in brain, lungs and abdomen. Electrochemical determination of amikacin is a challenge in electroanalysis because it shows no voltammetric peak at the surface of bare electrodes.
OBJECTIVE
OBJECTIVE
In this approach, a very simple and easy method for indirect voltammetric determination of amikacin presented in real samples. Gold nanoparticles were electrodeposited at the surface of glassy carbon electrode in constant potential.
METHODS
METHODS
The effect of several parameters such as time and potential of deposition, pH and scan rates on signal were studied. The cathodic peak current of Au
RESULTS
RESULTS
Two dynamic linear ranges of 1.0 × 10
CONCLUSION
CONCLUSIONS
The method was successfully determined amikacin in pharmaceutical preparation and human serum. The effect of several interference in determination of amikacin was also studied.
Identifiants
pubmed: 32682378
pii: CDD-EPUB-108260
doi: 10.2174/1567201817666200719005919
doi:
Substances chimiques
Gold
7440-57-5
Amikacin
84319SGC3C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
761-769Informations de copyright
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