Engulfment of Toxic Amyloid β-protein in Neurons and Astrocytes Mediated by MEGF10.
MEGF10
amyloid-β protein
draper
phagocytosis receptor
phosphorylation
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
19
03
2020
revised:
30
06
2020
accepted:
10
07
2020
pubmed:
20
7
2020
medline:
15
5
2021
entrez:
20
7
2020
Statut:
ppublish
Résumé
Amyloid-β proteins (A β), including Aβ42 and A β 43, are known pathogenesis factors of Alzheimer's disease (AD). Unwanted substances in the brain, including A β, are generally removed by microglia, astrocytes, or neurons via a phagocytosis receptor. We observed that neurons and astrocytes engulfed A β 42 and A β 43, which are more neurotoxic than A β 40. We previously showed that multiple-EGF like domains 10 (MEGF10) plays an important role in apoptotic cell elimination and is expressed in mammalian neurons and astrocytes. Therefore, we assessed whether MEGF10 is involved in A β42 and A β43 engulfment in MEGF10-expressing neurons and astrocytes. We found that MEGF10-expressing astrocytes and neurons engulfed A β42 and A β43 but not A β40. Furthermore, incubation of the neurons and astrocytes with A β42 and A β43a ugmented MEGF10 phosphorylation; however, incubation with A β40 did not have this augmenting effect. Our findings suggest that MEGF10 plays a phagocytosis receptor function for A β42 and A β43 in neurons and astrocytes.
Identifiants
pubmed: 32682823
pii: S0306-4522(20)30449-8
doi: 10.1016/j.neuroscience.2020.07.016
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.