Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig.
Antiviral
Ebola virus disease
Favipiravir
Guinea Pig
Pyronaridine
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
26
03
2020
revised:
15
06
2020
accepted:
16
06
2020
pubmed:
20
7
2020
medline:
13
7
2021
entrez:
20
7
2020
Statut:
ppublish
Résumé
The recent outbreaks of the Ebola virus (EBOV) in Africa have brought global visibility to the shortage of available therapeutic options to treat patients infected with this or closely related viruses. We have recently computationally identified three molecules which have all demonstrated statistically significant efficacy in the mouse model of infection with mouse adapted Ebola virus (ma-EBOV). One of these molecules is the antimalarial pyronaridine tetraphosphate (IC
Identifiants
pubmed: 32682926
pii: S0166-3542(20)30277-1
doi: 10.1016/j.antiviral.2020.104863
pmc: PMC8194506
mid: NIHMS1613243
pii:
doi:
Substances chimiques
Antiviral Agents
0
Naphthyridines
0
pyronaridine
TD3P7Q3SG6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104863Subventions
Organisme : NCATS NIH HHS
ID : R21 TR001718
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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