Imaging niacin trafficking with positron emission tomography reveals in vivo monocarboxylate transporter distribution.
Journal
Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420
Informations de publication
Date de publication:
Historique:
received:
04
06
2020
revised:
30
06
2020
accepted:
04
07
2020
pubmed:
20
7
2020
medline:
8
2
2022
entrez:
20
7
2020
Statut:
ppublish
Résumé
A sufficient dietary intake of the vitamin niacin is essential for normal cellular function. Niacin is transported into the cells by the monocarboxylate transporters: sodium-dependent monocarboxylate transporter (SMCT1 and SMCT2) and monocarboxylate transporter (MCT1). Despite the importance of niacin in biological systems, surprisingly, its in vivo biodistribution and trafficking in living organisms has not been reported. The availability of niacin radiolabelled with the short-lived positron emitting radionuclide carbon-11 ([ [ Total synthesis time including HPLC purification was 25 ± 1 min from end of [ Here, we describe the efficient preparation of [
Identifiants
pubmed: 32683248
pii: S0969-8051(20)30175-X
doi: 10.1016/j.nucmedbio.2020.07.002
pmc: PMC7599079
pii:
doi:
Substances chimiques
Carbon Radioisotopes
0
Monocarboxylic Acid Transporters
0
Radiopharmaceuticals
0
Niacin
2679MF687A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-33Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K022733/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 212885/Z/18Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203148/Z/16/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.