Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities.
Anti-Bacterial Agents
/ pharmacology
Antineoplastic Agents
/ pharmacology
Antioxidants
/ pharmacology
Biological Assay
Biphenyl Compounds
/ chemistry
Cell Survival
Free Radical Scavengers
Gold
/ chemistry
Green Chemistry Technology
/ methods
HT29 Cells
Humans
Inhibitory Concentration 50
Metal Nanoparticles
/ chemistry
Microscopy, Electron
Nitric Oxide
/ chemistry
Particle Size
Picrates
/ chemistry
Seaweed
/ metabolism
Silver
/ chemistry
Staphylococcus aureus
/ metabolism
Vibrio
X-Ray Diffraction
Antibacterial
Antioxidant
Cytotoxic activity
Gold nanoparticles
Marine algae
Journal
Bioprocess and biosystems engineering
ISSN: 1615-7605
Titre abrégé: Bioprocess Biosyst Eng
Pays: Germany
ID NLM: 101088505
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
13
04
2020
accepted:
10
07
2020
pubmed:
20
7
2020
medline:
10
8
2021
entrez:
20
7
2020
Statut:
ppublish
Résumé
In this study, we report a green synthesis of pharmaceutically active gold nanoparticles from marine red alga Acanthophora spicifera by the reduction of chloroauric acid. The formation of A. spicifera-mediated gold nanoparticles (As-AuNPs) was characterized by several analytical techniques. The crystalline and face-centered cubic (fcc) structure were confirmed by X-ray diffraction (XRD) analysis. Electron microscopy results confirmed that As-AuNPs were spherical and the average size of particles was < 20 nm. As-AuNPs hold a significant level of antioxidant activities than A. spicifera extract. As-AuNPs exhibited the highest antibacterial activity against Vibrio harveyi than Staphylococcus aureus at 100 µg/ml. Furthermore, As-AuNPs exhibited the utmost cytotoxicity against human colon adenocarcinoma (HT-29) cells and registered the half-maximal inhibitory concentration (IC
Identifiants
pubmed: 32683506
doi: 10.1007/s00449-020-02408-3
pii: 10.1007/s00449-020-02408-3
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents
0
Antioxidants
0
Biphenyl Compounds
0
Free Radical Scavengers
0
Picrates
0
Nitric Oxide
31C4KY9ESH
Silver
3M4G523W1G
Gold
7440-57-5
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2231-2242Subventions
Organisme : Ministry of Human Resource Development
ID : F-24-51/ 2014-U
Organisme : Ministry of Human Resource Development
ID : Policy (TNMulti-Gen)
Organisme : Ministry of Human Resource Development
ID : Dept of E
Organisme : National Research Foundation of Korea
ID : 2018R1A6A1A03023584
Organisme : National Research Foundation of Korea
ID : 2019R1A2B5B01070542