The origins and genomic diversity of American Civil War Era smallpox vaccine strains.
Ancient DNA
Smallpox
Vaccination
Vaccinia virus
Journal
Genome biology
ISSN: 1474-760X
Titre abrégé: Genome Biol
Pays: England
ID NLM: 100960660
Informations de publication
Date de publication:
20 07 2020
20 07 2020
Historique:
received:
30
10
2019
accepted:
19
06
2020
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
8
7
2021
Statut:
epublish
Résumé
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolutionary relationships of smallpox vaccination viruses within the poxviruses as a whole.
Identifiants
pubmed: 32684155
doi: 10.1186/s13059-020-02079-z
pii: 10.1186/s13059-020-02079-z
pmc: PMC7370420
doi:
Substances chimiques
Smallpox Vaccine
0
Types de publication
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
175Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : CIHR
ID : PJT-156214
Pays : Canada
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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