Immune response in cutaneous leishmaniasis patients with healing
Cutaneous leishmaniasis
Immune response
Interferon gamma (IFNγ)
Interleukin 10 (IL-10)
Interleukin 5 (IL-5)
Soluble Leishmania antigen (SLA)
Journal
Iranian journal of microbiology
ISSN: 2008-3289
Titre abrégé: Iran J Microbiol
Pays: Iran
ID NLM: 101518404
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
21
7
2020
Statut:
ppublish
Résumé
The outcome of This study was carried out in leishmaniasis clinic of CRTSDL, TUMS, during March 2018 to March 2019. Peripheral blood mononuclear cells (PBMC) of volunteers with active healing and non-healing lesion (s) of cutaneous leishmaniasis (CL), volunteers with and without history of CL were cultured and stimulated with Soluble The results showed a significantly higher levels of IFN-γ in volunteers with active CL healing form ( IFN-γ production starts at early stage of cutaneous leishmaniasis and enhance during course of lesion healing, IFN-γ level is significantly higher in all patients compared to healthy volunteers, IFN-γ is significantly higher in patients with healing form than non-healing form of lesion.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
The outcome of
MATERIALS AND METHODS
METHODS
This study was carried out in leishmaniasis clinic of CRTSDL, TUMS, during March 2018 to March 2019. Peripheral blood mononuclear cells (PBMC) of volunteers with active healing and non-healing lesion (s) of cutaneous leishmaniasis (CL), volunteers with and without history of CL were cultured and stimulated with Soluble
RESULTS
RESULTS
The results showed a significantly higher levels of IFN-γ in volunteers with active CL healing form (
CONCLUSION
CONCLUSIONS
IFN-γ production starts at early stage of cutaneous leishmaniasis and enhance during course of lesion healing, IFN-γ level is significantly higher in all patients compared to healthy volunteers, IFN-γ is significantly higher in patients with healing form than non-healing form of lesion.
Types de publication
Journal Article
Langues
eng
Pagination
249-255Informations de copyright
Copyright© 2020 Iranian Neuroscience Society.
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