Factors associated with outcomes in organophosphate and carbamate poisoning: a retrospective study.
Atropine
Carbamate
Glycopyrrolate
Older age
Organophosphate
Pralidoxime
Journal
Toxicological research
ISSN: 1976-8257
Titre abrégé: Toxicol Res
Pays: Singapore
ID NLM: 101483324
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
07
05
2019
revised:
18
09
2019
accepted:
27
11
2019
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
21
7
2020
Statut:
epublish
Résumé
Organophosphate and carbamate (OPC) poisoning is a major global health hazard requiring immediate medical intervention. Atropine (ATR) is an essential antidote in organophosphate and carbamate poisoning, with the inclusion of cholinesterase reactivators and other anticholinergics, namely pralidoxime (PAM) and glycopyrrolate (GPR). This study aimed to compare the efficacy of various treatment regimens and identify the factors affecting mortality. The data of patients presented at the emergency unit with the consumption of OPC compounds between the years 2013 and 2017 were retrospectively reviewed. The study population was then categorized into four treatment patterns (1) ATR alone, (2) ATR and PAM, (3) ATR and GPR, (4) ATR, PAM and GPR. The outcome of the patients was assessed in terms of survival, intubation, ICU days, and days of ventilation and hospitalization. Univariate and multivariate analyses were performed to investigate the risk factors associated with mortality and odds ratio (OR). A total of 441 patients were included in the study, of which 69.16% were males, and 375 patients survived. Consumption of poison with a suicidal intention was reported in 98.19% of the patients, and the treatment with ATR and PAM (42.86%) was observed to have lower days of ventilation in comparison to the treatment with ATR and GPR (
Identifiants
pubmed: 32685430
doi: 10.1007/s43188-019-00029-x
pii: 29
pmc: PMC7351927
doi:
Types de publication
Journal Article
Langues
eng
Pagination
257-266Informations de copyright
© Korean Society of Toxicology 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interests.
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