Comparison of mechanical, chemical and physical human models of in vivo skin damage: Randomized controlled trial.
in vivo skin damage models
non-invasive methods
skin barrier recovery
sodium lauryl sulphate
tape stripping
ultraviolet radiation
Journal
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
ISSN: 1600-0846
Titre abrégé: Skin Res Technol
Pays: England
ID NLM: 9504453
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
revised:
17
06
2020
received:
09
03
2020
accepted:
25
06
2020
pubmed:
21
7
2020
medline:
19
8
2021
entrez:
21
7
2020
Statut:
ppublish
Résumé
Human in vivo models of skin damage were often used in research of cutaneous disorders. The most commonly used models were tape-stripping as mechanical, sodium lauryl sulphate-induced irritation as chemical and ultraviolet radiation as physical damage model. In regard to differences between models, they were expected to have different responses to damage and recovery, with unique skin parameters' changes over time. The aim was to compare skin parameters in three different skin damage models on the same anatomical location, with and without topical treatment. Four test sites on each forearm were randomly assigned to three skin damage models with the fourth sites on each forearm chosen as a control, undamaged site. Skin parameters were assessed using non-invasive methods. Sodium lauryl sulphate irritation caused the strongest damage with delayed reaction to the irritant. Tape stripping leads to highest initial skin barrier disruption but afterwards it showed the fastest skin recovery. Ultraviolet radiation did not affect skin barrier function, but it elevated skin erythema and melanin level. Tested preparation did not lead to changes in measured parameters. The skin of the participants had different response to three skin damage models with distinct changes of skin parameters and recovery. The trial was registered at ClinicalTrials.gov under the identifier NCT03783819.
Substances chimiques
Sodium Dodecyl Sulfate
368GB5141J
Banques de données
ClinicalTrials.gov
['NCT03783819']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
208-216Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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