Obesity is a risk factor for developing critical condition in COVID-19 patients: A systematic review and meta-analysis.
COVID-19
intensive care
mechanical ventilation
obesity
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
ISSN: 1467-789X
Titre abrégé: Obes Rev
Pays: England
ID NLM: 100897395
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
02
06
2020
revised:
14
06
2020
accepted:
21
06
2020
pubmed:
21
7
2020
medline:
23
9
2020
entrez:
21
7
2020
Statut:
ppublish
Résumé
The disease course of COVID-19 varies from asymptomatic infection to critical condition leading to mortality. Identification of prognostic factors is important for prevention and early treatment. We aimed to examine whether obesity is a risk factor for the critical condition in COVID-19 patients by performing a meta-analysis. The review protocol was registered onto PROSPERO (CRD42020185980). A systematic search was performed in five scientific databases between 1 January and 11 May 2020. After selection, 24 retrospective cohort studies were included in the qualitative and quantitative analyses. We calculated pooled odds ratios (OR) with 95% confidence intervals (CIs) in meta-analysis. Obesity was a significant risk factor for intensive care unit (ICU) admission in a homogenous dataset (OR = 1.21, CI: 1.002-1.46; I2 = 0.0%) as well as for invasive mechanical ventilation (IMV) (OR = 2.05, CI: 1.16-3.64; I2 = 34.86%) in COVID-19. Comparing body mass index (BMI) classes with each other, we found that a higher BMI always carries a higher risk. Obesity may serve as a clinical predictor for adverse outcomes; therefore, the inclusion of BMI in prognostic scores and improvement of guidelines for the intensive care of patients with elevated BMI are highly recommended.
Identifiants
pubmed: 32686331
doi: 10.1111/obr.13095
pmc: PMC7404429
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13095Subventions
Organisme : Economic Development and Innovation Operational Programme (European Regional Development Fund) within the framework of Programme Széchenyi 2020
ID : GINOP-2.3.2-15-2016-00048 - STAY ALIVE
Pays : International
Organisme : Human Resources Development Operational Programme (European Regional Development Fund)
ID : EFOP 3.6.2-16-2017-00006 - LIVE LONGER
Pays : International
Organisme : Medical School of University of Pécs
Pays : International
Informations de copyright
© 2020 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
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