Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 07 2020
20 07 2020
Historique:
received:
11
02
2020
accepted:
25
06
2020
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
29
8
2020
Statut:
epublish
Résumé
Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any encapsulated contents, in vivo. Herein, we describe, and visualise in real time, light-triggered switching of liposome surface charge, from neutral to cationic, in situ and in vivo (embryonic zebrafish). Prior to light activation, intravenously administered liposomes, composed of just two lipid reagents, freely circulate and successfully evade innate immune cells present in the fish. Upon in situ irradiation and surface charge switching, however, liposomes rapidly adsorb to, and are taken up by, endothelial cells and/or are phagocytosed by blood resident macrophages. Coupling complete external control of nanoparticle targeting together with the intracellular delivery of encapsulated (and membrane impermeable) cargos, these compositionally simple liposomes are proof that advanced nanoparticle function in vivo does not require increased design complexity but rather a thorough understanding of the fundamental nano-bio interactions involved.
Identifiants
pubmed: 32686667
doi: 10.1038/s41467-020-17360-9
pii: 10.1038/s41467-020-17360-9
pmc: PMC7371701
doi:
Substances chimiques
Cations
0
Liposomes
0
Banques de données
figshare
['10.6084/m9.figshare.12387629']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3638Références
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