Decreased bioefficacy of long-lasting insecticidal nets and the resurgence of malaria in Papua New Guinea.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 07 2020
20 07 2020
Historique:
received:
03
03
2020
accepted:
30
06
2020
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
29
8
2020
Statut:
epublish
Résumé
Papua New Guinea (PNG) has the highest malaria transmission outside of Africa. Long-lasting insecticidal nets (LLINs) are believed to have helped to reduce average malaria prevalence in PNG from 16% in 2008 to 1% in 2014. Since 2015 malaria in PNG has resurged significantly. Here, we present observations documenting decreased bioefficacy of unused LLINs with manufacturing dates between 2013 and 2019 collected from villages and LLIN distributors in PNG. Specifically, we show that of n = 167 tested LLINs manufactured after 2013, only 17% are fulfilling the required World Health Organisation bioefficacy standards of ≥ 80% 24 h mortality or ≥ 95% 60 min knockdown in bioassays with pyrethroid susceptible Anopheles farauti mosquitoes. In contrast, all (100%, n = 25) LLINs with manufacturing dates prior to 2013 are meeting these bioefficacy standards. These results suggest that decreased bioefficacy of LLINs is contributing to the malaria resurgence in PNG and increased scrutiny of LLIN quality is warranted.
Identifiants
pubmed: 32686679
doi: 10.1038/s41467-020-17456-2
pii: 10.1038/s41467-020-17456-2
pmc: PMC7371689
doi:
Substances chimiques
Insecticides
0
Pyrethrins
0
Banques de données
figshare
['10.6084/m9.figshare.12552137.v1']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3646Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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