Concomitant excitation and tension development are required for myocellular gene expression and protein synthesis in rat skeletal muscle.
EC-coupling
calcium
excitation
mechanotransduction
stretch
tension
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
20
12
2019
revised:
12
07
2020
accepted:
14
07
2020
pubmed:
21
7
2020
medline:
19
8
2021
entrez:
21
7
2020
Statut:
ppublish
Résumé
Loading-induced tension development is often assumed to constitute an independent cue to initiate muscle protein synthesis following resistance exercise. However, with traditional physiological models of resistance exercise, changes in loading-induced tension development also reflect changes in neural activation patterns, and direct evidence for a mechanosensitive mechanism is therefore limited. Here, we sought to examine the importance of excitation and tension development per se on initiation of signalling, gene transcription and protein synthesis in rat skeletal muscle. Isolated rat extensor digitorum longus muscles were allocated to the following interventions: (a) Excitation-induced eccentric contractions (ECC); (b) Passive stretching without excitation (PAS); (c) Excitation with inhibition of contractions (STIM + I Protein synthesis increased solely in muscles subjected to a combination of excitation and tension development (ECC and STIM + I The current study suggests that exercise-induced increases in protein synthesis as well as transcriptional signalling is dependent on the concomitant effect of excitation and tension development, whereas signalling for translation initiation is only dependent of tension development per se.
Substances chimiques
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13540Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
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