Maternal Sleep-Disordered Breathing in Pregnancy and Increased Nocturnal Glucose Levels in Women with Gestational Diabetes Mellitus.

Adult Blood Glucose Body Mass Index Cross-Sectional Studies Diabetes, Gestational / blood Female Humans Polysomnography Pregnancy Severity of Illness Index Sleep Apnea Syndromes / blood
gestational diabetes mellitus glucose levels hyperglycemia maternal sleep-disordered breathing

Journal

Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335

Informations de publication

Date de publication:
01 2021
Historique:
received: 02 01 2020
revised: 22 06 2020
accepted: 02 07 2020
pubmed: 21 7 2020
medline: 12 6 2021
entrez: 21 7 2020
Statut: ppublish

Résumé

Women with hyperglycemia during pregnancy are at high risk for adverse perinatal outcomes. Maternal sleep-disordered breathing (SDB) during pregnancy is common and is a risk factor for gestational diabetes mellitus (GDM). However, the relationship between SDB severity and glucose control is unknown. Is there an association between SDB severity and glucose levels as assessed by continuous glucose monitoring in GDM? Women with GDM underwent sleep recordings and 72-hour continuous glucose monitoring. Linear mixed models were used to estimate the association of the apnea-hypopnea index (AHI), rapid eye movement (REM)-AHI, and non-REM-AHI with mean glucose levels during nighttime (two periods: 11 pm to 3 am and 3 am to 6 am), daytime (8 am to 9 pm), and 24-hours. Models were adjusted for BMI and antihyperglycemic medications. In 65 participants who were 35 ± 5 (mean ± SD) years of age with BMI of 33 ± 7 kg/m Greater severity of SDB was associated with higher nocturnal and morning glucose levels in women with GDM.

Sections du résumé

BACKGROUND
Women with hyperglycemia during pregnancy are at high risk for adverse perinatal outcomes. Maternal sleep-disordered breathing (SDB) during pregnancy is common and is a risk factor for gestational diabetes mellitus (GDM). However, the relationship between SDB severity and glucose control is unknown.
RESEARCH QUESTION
Is there an association between SDB severity and glucose levels as assessed by continuous glucose monitoring in GDM?
STUDY DESIGN AND METHODS
Women with GDM underwent sleep recordings and 72-hour continuous glucose monitoring. Linear mixed models were used to estimate the association of the apnea-hypopnea index (AHI), rapid eye movement (REM)-AHI, and non-REM-AHI with mean glucose levels during nighttime (two periods: 11 pm to 3 am and 3 am to 6 am), daytime (8 am to 9 pm), and 24-hours. Models were adjusted for BMI and antihyperglycemic medications.
RESULTS
In 65 participants who were 35 ± 5 (mean ± SD) years of age with BMI of 33 ± 7 kg/m
INTERPRETATION
Greater severity of SDB was associated with higher nocturnal and morning glucose levels in women with GDM.

Identifiants

DOI: 10.1016/j.chest.2020.07.014 PMID: 32687908
pubmed: 32687908
pii: S0012-3692(20)31911-5
doi: 10.1016/j.chest.2020.07.014
pii:
doi:

Substances chimiques

Blood Glucose 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

356-365

Subventions

Organisme : CIHR
ID : 136886
Pays : Canada
Organisme : CIHR
ID : 164317
Pays : Canada

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Auteurs

Raphieal Newbold (R)

Centre for Outcomes Research and Evaluation (CORE) of the Research Institute, McGill University Health Centre, Montreal, QC, Canada.

Andrea Benedetti (A)

Centre for Outcomes Research and Evaluation (CORE) of the Research Institute, McGill University Health Centre, Montreal, QC, Canada; Departments of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.

R John Kimoff (RJ)

Centre for Outcomes Research and Evaluation (CORE) of the Research Institute, McGill University Health Centre, Montreal, QC, Canada; Division of Respiratory Medicine, Department of Medicine, McGill University, Montreal, QC, Canada.

Sara Meltzer (S)

Division of Endocrinology, Department of Medicine, McGill University, Montreal, QC, Canada.

Natasha Garfield (N)

Division of Endocrinology, Department of Medicine, McGill University, Montreal, QC, Canada.

Kaberi Dasgupta (K)

Centre for Outcomes Research and Evaluation (CORE) of the Research Institute, McGill University Health Centre, Montreal, QC, Canada; Divisions of Internal Medicine, Clinical Epidemiology and Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, QC, Canada.

Robert Gagnon (R)

Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada.

Lorraine Lavigne (L)

Division of Respiratory Medicine, Department of Medicine, McGill University, Montreal, QC, Canada.

Allen Olha (A)

Division of Respiratory Medicine, Department of Medicine, McGill University, Montreal, QC, Canada.

Evelyne Rey (E)

Faculté de médecine, Département de médecine, Université de Montréal, Montreal, QC, Canada.

Sushmita Pamidi (S)

Centre for Outcomes Research and Evaluation (CORE) of the Research Institute, McGill University Health Centre, Montreal, QC, Canada; Division of Respiratory Medicine, Department of Medicine, McGill University, Montreal, QC, Canada. Electronic address: Sushmita.pamidi@mcgill.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète gestationnel › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Polysomnographie › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Maternal Sleep-Disordered Breathing in...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Maternal Sleep-Disordered Breathing in...