Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance.
Animals
Diet, High-Fat
/ adverse effects
Inflammasomes
/ metabolism
Insulin Resistance
Liver
/ drug effects
Male
Marine Toxins
/ toxicity
Mice
Mice, Inbred C57BL
Microcystins
/ toxicity
NLR Family, Pyrin Domain-Containing 3 Protein
/ metabolism
Non-alcoholic Fatty Liver Disease
/ chemically induced
Water Pollutants, Chemical
/ toxicity
GLUT4
Hexokinase
IRS
Inflammasome
MC-LR
Microcystin
NLRP3
PEPCK
Journal
Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
11
03
2020
revised:
19
06
2020
accepted:
14
07
2020
pubmed:
21
7
2020
medline:
11
2
2021
entrez:
21
7
2020
Statut:
ppublish
Résumé
Evidence from pediatric studies show that infants and children are at risk for early exposure to microcystin. The present report tests the hypothesis that early life exposure to microcystin (MC), a principal component of harmful algal blooms followed by a juvenile exposure to high-fat diet feeding potentiate the development of nonalcoholic fatty liver disease phenotype in adulthood. Results showed classical symptoms of early NAFLD linked inflammation. Cytokines and chemokines such as CD68, IL-1β, MCP-1, and TNF-α, as well as α-SMA were increased in the groups that were exposed to MC-LR with the high-fat diet compared to the vehicle group. Also, mechanistically, NLRP3 KO mice showed a significant decrease in the inflammation and NAFLD phenotype and resisted the metabolic changes such as insulin resistance and glucose metabolism in the liver. The data suggested that MC-LR exposure and subsequent NLRP3 inflammasome activation in childhood could impact liver health in juveniles.
Identifiants
pubmed: 32687983
pii: S1382-6689(20)30133-2
doi: 10.1016/j.etap.2020.103457
pmc: PMC7609636
mid: NIHMS1615999
pii:
doi:
Substances chimiques
Inflammasomes
0
Marine Toxins
0
Microcystins
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Nlrp3 protein, mouse
0
Water Pollutants, Chemical
0
cyanoginosin LR
EQ8332842Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103457Subventions
Organisme : CSRD VA
ID : I01 CX001923
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019313
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103641
Pays : United States
Organisme : NCCIH NIH HHS
ID : P01 AT003961
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT006888
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES028942
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094755
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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