Short chain fatty acids: Postbiotics/metabolites and graft versus host disease colitis.
Acute graft vs host disease
Allogeneic stem cell transplant
Metabolites
Microbiome
Short chain fatty acids
Journal
Seminars in hematology
ISSN: 1532-8686
Titre abrégé: Semin Hematol
Pays: United States
ID NLM: 0404514
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
03
02
2020
revised:
07
05
2020
accepted:
02
06
2020
entrez:
22
7
2020
pubmed:
22
7
2020
medline:
16
4
2021
Statut:
ppublish
Résumé
Acute Graft vs host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo HSCT), a potent form of cellular therapy that has the potential to cure malignant and benign hematological conditions. Gastrointestinal (GI) GVHD is the principal cause of nonrelapse mortality after allo HSCT. Allo HSCT alters the intestinal microbiota and recent research uncovered a microbiome-metabolome axis that can affect intestinal homeostasis and mitigate the severity of experimental GI GVHD. This axis can potentially be manipulated via dietary intervention or through probiotics or postbiotics or antibiotics in humans. In this review we summarize major findings of how microbial metabolites and particularly short chain fatty acids (SCFAs) could impact acute GI GVHD.
Identifiants
pubmed: 32690138
pii: S0037-1963(20)30004-4
doi: 10.1053/j.seminhematol.2020.06.001
pmc: PMC9387163
mid: NIHMS1603068
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Subventions
Organisme : NCI NIH HHS
ID : P01 CA039542
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA173878
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203542
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090775
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of Interest The authors have no conflicts of interest to disclose.
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