Control of the chromatin response to DNA damage: Histone proteins pull the strings.
Chromatin dynamics
DNA damage repair
Histone post-translational modifications
Histone variants
Transcriptional regulation
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
12
03
2020
revised:
29
06
2020
accepted:
01
07
2020
pubmed:
22
7
2020
medline:
3
2
2022
entrez:
22
7
2020
Statut:
ppublish
Résumé
DNA damage challenges both genome integrity and its organization with histone proteins into chromatin, with prominent alterations in histone variant dynamics and histone modifications. While these alterations jeopardize epigenome stability, they are also instrumental for an efficient and timely response to DNA damage. Here, we review recent findings illustrating how histone variants and post-translational modifications actively contribute to and control the DNA damage response. We present accumulating evidence that histone protein changes help relieve the chromatin barrier to DNA repair by regulating chromatin compaction and mobility. We also highlight how histone modifications and variants control transcriptional silencing at damage sites, and we describe both pre-existing and DNA damage-induced chromatin features that govern DNA damage signaling and guide DNA repair pathway choice. We discuss how histone dynamics ultimately participate to the restoration of epigenome integrity and present our current knowledge of key molecular players involved in these critical processes.
Identifiants
pubmed: 32690375
pii: S1084-9521(19)30096-5
doi: 10.1016/j.semcdb.2020.07.002
pii:
doi:
Substances chimiques
Chromatin
0
Histones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-87Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.