Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy.
ER-phagy
Vps13
autophagy
contact site
lipid transporter
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
04 08 2020
04 08 2020
Historique:
pubmed:
22
7
2020
medline:
2
10
2020
entrez:
22
7
2020
Statut:
ppublish
Résumé
Endoplasmic reticulum (ER) macroautophagy (hereafter called ER-phagy) uses autophagy receptors to selectively degrade ER domains in response to starvation or the accumulation of aggregation-prone proteins. Autophagy receptors package the ER into autophagosomes by binding to the ubiquitin-like yeast protein Atg8 (LC3 in mammals), which is needed for autophagosome formation. In budding yeast, cortical and cytoplasmic ER-phagy requires the autophagy receptor Atg40. While different ER autophagy receptors have been identified, little is known about other components of the ER-phagy machinery. In an effort to identify these components, we screened the genome-wide library of viable yeast deletion mutants for defects in the degradation of cortical ER following treatment with rapamycin, a drug that mimics starvation. Among the mutants we identified was
Identifiants
pubmed: 32690699
pii: 2008923117
doi: 10.1073/pnas.2008923117
pmc: PMC7414049
doi:
Substances chimiques
Saccharomyces cerevisiae Proteins
0
VPS13 protein, S cerevisiae
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18530-18539Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131681
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM115422
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM035370
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114111
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM082861
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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