[The Effect of PAMAM Dendrimer on the Dentin Remineralization and Matrix Metalloproteinases Activity].
Biomimetic mineralization
Dentin
Gelatinase
Matrix metalloproteinases
PAMAM dendrimer
Journal
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
ISSN: 1672-173X
Titre abrégé: Sichuan Da Xue Xue Bao Yi Xue Ban
Pays: China
ID NLM: 101162609
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
entrez:
22
7
2020
pubmed:
22
7
2020
medline:
18
11
2020
Statut:
ppublish
Résumé
The purpose of this study was to investigate the effect of G4.5 carboxyl-terminated poly dendrimer (PAMAM-COOH) on the dentin remineralization and the matrix metalloproteinases (MMPs) activity. The dentine samples were averagely divided into four groups: 100 mg/mL PAMAM-COOH group (A group), 10 mg/mL PAMAM-COOH group (B group), 2% (wt) chlorhexidine (CHX) group (C group) and deionized water group (Control group). MMP Activity Assay Kit was used to detect the activity of dentin endogenous MMPs in the four groups. The loss of dry mass of dentin after 30 d were measured. Compared with the control group, the dentin endogenous MMPs activity in A, B and C groups were all decreased ( G4.5 PAMAM-COOH could introduce remineralizationin and demineralizeddentin by effectively inhibiting endogenous MMPs and gelatinase, thus contributes as novel material to enhancing durability of adhesion.
Identifiants
pubmed: 32691557
doi: 10.12182/20200760203
doi:
Substances chimiques
Dendrimers
0
PAMAM Starburst
0
Saliva, Artificial
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Langues
chi
Sous-ensembles de citation
IM
Pagination
499-504Informations de copyright
Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).