Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.

Black or African American / ethnology Cohort Studies Genetic Predisposition to Disease / ethnology Genome-Wide Association Study / methods Humans Polymorphism, Single Nucleotide / genetics Stroke / ethnology
brain ischemia coronary artery disease genome-wide association study meta-analysis phenotype risk factors

Journal

Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266

Informations de publication

Date de publication:
08 2020
Historique:
pubmed: 23 7 2020
medline: 5 11 2020
entrez: 23 7 2020
Statut: ppublish

Résumé

Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans. The COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts. In meta-analyses, we identified one single nucleotide polymorphism (rs55931441) near the These findings represent the most thorough investigation of genetic determinants of stroke in individuals of African descent, to date.

Sections du résumé

BACKGROUND AND PURPOSE
Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans.
METHODS
The COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts.
RESULTS
In meta-analyses, we identified one single nucleotide polymorphism (rs55931441) near the
CONCLUSIONS
These findings represent the most thorough investigation of genetic determinants of stroke in individuals of African descent, to date.

Identifiants

DOI: 10.1161/STROKEAHA.120.029123 PMID: 32693751 PMC: PMC7387190
pubmed: 32693751
doi: 10.1161/STROKEAHA.120.029123
pmc: PMC7387190
mid: NIHMS1606377
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2454-2463

Subventions

Organisme : NHGRI NIH HHS
ID : U01 HG005160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103612
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS107230
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200800007C
Pays : United States
Organisme : Medical Research Council
ID : MC_EX_MR/M009203/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS041588
Pays : United States
Organisme : Medical Research Council
ID : G9521010
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL138423
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH22110
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800012C
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS045012
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Organisme : Intramural NIH HHS
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Pays : United States
Organisme : NINDS NIH HHS
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Pays : United States
Organisme : NHGRI NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Organisme : NCRR NIH HHS
ID : UL1 RR025005
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Organisme : NHLBI NIH HHS
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Organisme : NIMHD NIH HHS
ID : L60 MD013112
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL059367
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NINDS NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004402
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC55222
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AG000954
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800014C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85086
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHGRI NIH HHS
ID : HHSN268200782096C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072488
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NIMHD NIH HHS
ID : HHSN268201800013I
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS069208
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200036C
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK084350
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS039987
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : Medical Research Council
ID : MR/M009203/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201800011C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85082
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034447
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004436
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105150
Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Organisme : NHLBI NIH HHS
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Organisme : NHLBI NIH HHS
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Organisme : NHLBI NIH HHS
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Organisme : NIA NIH HHS
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Organisme : NHLBI NIH HHS
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Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_14089
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR003098
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Keith L Keene (KL)

Department of Biology; Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC (K.L.K.).

Hyacinth I Hyacinth (HI)

Aflac Cancer and Blood Disorder Center of Emory University and Children's Healthcare of Atlanta University, GA (H.I.H.).

Joshua C Bis (JC)

University of Washington, Seattle, WA (J.C.B., W.T.L.).

Steven J Kittner (SJ)

Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD (S.J.K., B.D.M., Y.-C.C.).

Braxton D Mitchell (BD)

Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD (S.J.K., B.D.M., Y.-C.C.).

Yu-Ching Cheng (YC)

Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD (S.J.K., B.D.M., Y.-C.C.).

Guillaume Pare (G)

McMaster University and Population Health Research Institute, Hamilton Ontario (G.P., M.C.).

Michael Chong (M)

McMaster University and Population Health Research Institute, Hamilton Ontario (G.P., M.C.).

Martin O'Donnell (M)

National University of Ireland Galway, Ireland (M.O.).

James F Meschia (JF)

Mayo Clinic Florida, Jacksonville (J.F.M.).

Wei-Min Chen (WM)

Center for Public Health Genomics, University of Virginia, Charlottesville (W.-M.C., M.M.S., S.S.R.).

Michèle M Sale (MM)

Center for Public Health Genomics, University of Virginia, Charlottesville (W.-M.C., M.M.S., S.S.R.).

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville (W.-M.C., M.M.S., S.S.R.).

Mike A Nalls (MA)

Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD (M.A.N.).
Data Tecnica International, Glen Echo, MD (M.A.N.).

Alan B Zonderman (AB)

Laboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD (A.B.Z., M.K.E.).

Michele K Evans (MK)

Laboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD (A.B.Z., M.K.E.).

James G Wilson (JG)

University of Mississippi Medical Center, Jackson (J.G.W., A.C., T.H.M.).

Adolfo Correa (A)

University of Mississippi Medical Center, Jackson (J.G.W., A.C., T.H.M.).

Hugh S Markus (HS)

University of Cambridge, England, United Kingdom (H.S.M.).

Matthew Traylor (M)

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.T.).

Cathryn M Lewis (CM)

Social, Genetic and Developmental Psychiatry Centre, King's College London, United Kingdom (C.M.L.).

Cara L Carty (CL)

Initiative for Research and Education to Advance Community Health, Washington State University, Seattle (C.L.C.).

Alexander Reiner (A)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.R., J.H., C.K.).

Jeff Haessler (J)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.R., J.H., C.K.).

Carl D Langefeld (CD)

Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., C.L.).

Rebecca Gottesman (R)

Johns Hopkins University School of Medicine, Baltimore, MD (R.G.).

Thomas H Mosley (TH)

University of Mississippi Medical Center, Jackson (J.G.W., A.C., T.H.M.).

Daniel Woo (D)

Department of Neurology, University of Cincinnati, OH (D.W.).

Kristine Yaffe (K)

University of California, San Francisco (K.Y.).

YongMei Liu (Y)

Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., C.L.).

William T Longstreth (WT)

University of Washington, Seattle, WA (J.C.B., W.T.L.).

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle (B.M.P.).
Kaiser Permanente Washington Health Research Institute, Seattle, WA (B.M.P.).

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.R., J.H., C.K.).

Leslie A Lange (LA)

University of Colorado Anschutz Medical Campus, Denver (L.A.L.).

Ralph Sacco (R)

University of Miami, Miller School of Medicine, FL (R.S., T.R.).

Tatjana Rundek (T)

University of Miami, Miller School of Medicine, FL (R.S., T.R.).

Jin-Moo Lee (JM)

Washington University School of Medicine, St. Louis, MO (J.-M.L., C.C.).

Carlos Cruchaga (C)

Washington University School of Medicine, St. Louis, MO (J.-M.L., C.C.).

Karen L Furie (KL)

Brown University Warren Alpert Medical School, Providence, RI (K.L.F.).

Donna K Arnett (DK)

University of Kentucky, College of Public Health, Lexington (D.K.A.).

Oscar R Benavente (OR)

University of British Columbia, Vancouver, (O.R.B.).

Raji P Grewal (RP)

Neuroscience Institute, Saint Francis Medical Center, Trenton, NJ (R.P.G., L.R.P.).

Leema Reddy Peddareddygari (LR)

Neuroscience Institute, Saint Francis Medical Center, Trenton, NJ (R.P.G., L.R.P.).

Martin Dichgans (M)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., R.M.).
Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.).

Rainer Malik (R)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., R.M.).

Bradford B Worrall (BB)

Department of Neurology, University of Virginia, Charlottesville (B.B.W.).

Myriam Fornage (M)

Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (M.F.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Populations d'origine continentale › Noir ou Africain Américain › Genome-Wide Association Study Meta-Analysis of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Genome-Wide Association Study Meta-Analysis of...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genome-Wide Association Study Meta-Analysis of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-Wide Association Study Meta-Analysis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-Wide Association Study Meta-Analysis of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genome-Wide Association Study Meta-Analysis of...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Genome-Wide Association Study Meta-Analysis of...