Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.

Diabetes Mellitus, Type 2 / drug therapy Endothelium, Vascular Exercise Humans Insulin Insulin Resistance
Endothelial dysfunction exercise hypertension insulin pharmacological vascular function

Journal

Current pharmaceutical design
ISSN: 1873-4286
Titre abrégé: Curr Pharm Des
Pays: United Arab Emirates
ID NLM: 9602487

Informations de publication

Date de publication:
2020
Historique:
received: 11 02 2020
accepted: 04 06 2020
pubmed: 23 7 2020
medline: 20 1 2021
entrez: 23 7 2020
Statut: ppublish

Résumé

Endothelial dysfunction is a hallmark of type 2 diabetes that can have severe consequences on vascular function, including hypertension and changes in blood flow, as well as exercise performance. Because endothelium is also the barrier for insulin movement into tissues, it acts as a gatekeeper for transport and glucose uptake. For this reason, endothelial dysfunction is a tempting area for pharmacological and/or exercise intervention with insulin-based therapies. In this review, we describe the current state of drugs that can be used to treat endothelial dysfunction in type 2 diabetes and diabetes-related diseases (e.g., obesity) at the molecular levels, and also discuss their role in exercise.

Identifiants

DOI: 10.2174/1381612826666200721002735 PMID: 32693765 PMC: PMC8011202
pubmed: 32693765
pii: CPD-EPUB-108344
doi: 10.2174/1381612826666200721002735
pmc: PMC8011202
mid: NIHMS1680667
doi:

Substances chimiques

Insulin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3760-3767

Subventions

Organisme : NHLBI NIH HHS
ID : T32 HL007284
Pays : United States

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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Auteurs

Melissa A Luse (MA)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.

Emily M Heiston (EM)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.

Steven K Malin (SK)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.

Brant E Isakson (BE)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Cellular and Functional Effects of Insulin...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Cellular and Functional Effects of Insulin...
questionsmedicales.fr › Activités humaines › Exercice physique › Cellular and Functional Effects of Insulin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cellular and Functional Effects of Insulin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Cellular and Functional Effects of Insulin...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Cellular and Functional Effects of Insulin...