Leader β-cells coordinate Ca

Animals Calcium / metabolism Glucose / metabolism In Vitro Techniques Insulin / metabolism Insulin-Secreting Cells / metabolism Signal Transduction Zebrafish / metabolism

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
06 2019
Historique:
received: 19 06 2018
accepted: 08 05 2019
entrez: 23 7 2020
pubmed: 23 7 2020
medline: 7 1 2021
Statut: ppublish

Résumé

Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In the present study, we used the recombinant Ca

Identifiants

DOI: 10.1038/s42255-019-0075-2 PMID: 32694805
pubmed: 32694805
doi: 10.1038/s42255-019-0075-2
pii: 10.1038/s42255-019-0075-2
doi:

Substances chimiques

Insulin 0
Glucose IY9XDZ35W2
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

615-629

Subventions

Organisme : Medical Research Council
ID : MR/L020149/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S025618/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K001981/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N020472/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N00275X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M012646/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L02036X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201325/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 212625/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K023667/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R022259/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT098424AIA
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010676/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J0003042/1
Pays : United Kingdom

Auteurs

Victoria Salem (V)

Department of Medicine, Imperial College London, London, UK. v.salem@imperial.ac.uk.
ORCID: 0000-0001-6463-7471

Luis Delgadillo Silva (LD)

Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.

Kinga Suba (K)

Department of Medicine, Imperial College London, London, UK.

Eleni Georgiadou (E)

Department of Medicine, Imperial College London, London, UK.

S Neda Mousavy Gharavy (S)

Department of Medicine, Imperial College London, London, UK.

Nadeem Akhtar (N)

Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.

Aldara Martin-Alonso (A)

Department of Medicine, Imperial College London, London, UK.

David C A Gaboriau (DCA)

Facility for Imaging by Light Microscopy, Imperial College London, London, UK.
ORCID: 0000-0003-4047-6487

Stephen M Rothery (SM)

Facility for Imaging by Light Microscopy, Imperial College London, London, UK.

Theodoros Stylianides (T)

Loughborough University, Loughborough, UK.

Gaelle Carrat (G)

Department of Medicine, Imperial College London, London, UK.

Timothy J Pullen (TJ)

Department of Diabetes, Faculty of Life Science and Medicine, King's College London, London, UK.

Sumeet Pal Singh (SP)

Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-5154-3318

David J Hodson (DJ)

Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, UK.
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Nottingham, UK.

Isabelle Leclerc (I)

Department of Medicine, Imperial College London, London, UK.

A M James Shapiro (AMJ)

Clinical Islet Laboratory and Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.

Piero Marchetti (P)

University of Pisa, Pisa, Italy.

Linford J B Briant (LJB)

Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Walter Distaso (W)

Imperial College London, London, UK.

Nikolay Ninov (N)

Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany. nikolay.ninov@tu-dresden.de.
Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the University Hospital Carl Gustav Carus of TU Dresden, German Center for Diabetes Research, Dresden, Germany. nikolay.ninov@tu-dresden.de.
ORCID: 0000-0003-3286-6100

Guy A Rutter (GA)

Department of Medicine, Imperial College London, London, UK. g.rutter@imperial.ac.uk.
ORCID: 0000-0001-6360-0343

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Leader β-cells coordinate Ca
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Leader β-cells coordinate Ca
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Leader β-cells coordinate Ca
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Leader β-cells coordinate Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Leader β-cells coordinate Ca
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Leader β-cells coordinate Ca
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Leader β-cells coordinate Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Leader β-cells coordinate Ca